Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-41847
Boyman, O; Cho, J H; Sprent, J (2010). The role of interleukin-2 in memory CD8 cell differentiation. In: Zanetti, M; Schoenberger, S P. Memory T Cells. New York, 28-41. ISBN 978-1-4419-6450-2 (P) 978-1-4419-6451-9 (E).
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The current literature on the role of interleukin (IL)-2 in memory CD8+ T-cell differentiation indicates a significant contribution of IL-2 during primary and also secondary expansion of CD8+ T cells. IL-2 seems to be responsible for optimal expansion and generation of effector functions following primary antigenic challenge. As the magnitude of T-cell expansion determines the numbers of memory CD8+ T cells surviving after pathogen elimination, these event influence memory cell generation. Moreover, during the contraction phase of an immune respons where most antigen-specific CD8+ T cells disappear by apoptosis, IL-2 signals are able to rescu CD8+ T cells from cell death and provide a durable increase in memory CD8+ T-cell counts. At the memory stage, CD8+ T-cell frequencies can be boosted by administration of exogenous IL-2 Significantly, only CD8+ T cells that have received IL-2 signals during initial priming are able t mediate efficient secondary expansion following renewed antigenic challenge. Thus, IL-2 signals during different phases of an immune response are key in optimizing CD8+ T-cell functions, thereby affecting both primary and secondary responses of these T cells.
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|Item Type:||Book Section, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Dermatology Clinic|
|DDC:||610 Medicine & health|
|Deposited On:||08 Jan 2011 16:47|
|Last Modified:||23 Nov 2012 17:57|
|Series Name:||Advances in Experimental Medicine and Biology|
|ISBN:||978-1-4419-6450-2 (P) 978-1-4419-6451-9 (E)|
|Additional Information:||The original publication is available at www.springerlink.com|
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