Quick Search:

uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-42259

Srivastava, M; Simakov, O; Chapman, J; Fahey, B; Gauthier, M E A; Mitros, T; Richards, G S; Conaco, C; Dacre, M; Hellsten, U; Larroux, C; Putnam, N H; Stanke, M; Adamska, M; Darling, A; Degnan, S M; Oakley, T H; Plachetzki, D C; Zhai, Y; Adamski, M; Calcino, A; Cummins, S F; Goodstein, D M; Harris, C; Jackson, D J; Leys, S P; Shu, S; Woodcroft, B J; Vervoort, M; Kosik, K S; Manning, G; Degnan, B M; Rokhsar, D S (2010). The Amphimedon queenslandica genome and the evolution of animal complexity. Nature, 466(7307):720-726.

[img] PDF - Registered users only
1MB

View at publisher

Abstract

Sponges are an ancient group of animals that diverged from other metazoans over 600 million years ago. Here we present the draft genome sequence of Amphimedon queenslandica, a demosponge from the Great Barrier Reef, and show that it is remarkably similar to other animal genomes in content, structure and organization. Comparative analysis enabled by the sequencing of the sponge genome reveals genomic events linked to the origin and early evolution of animals, including the appearance, expansion and diversification of pan-metazoan transcription factor, signalling pathway and structural genes. This diverse `toolkit' of genes correlates with critical aspects of all metazoan body plans, and comprises cell cycle control and growth, development, somatic-and germ-cell specification, cell adhesion, innate immunity and allorecognition. Notably, many of the genes associated with the emergence of animals are also implicated in cancer, which arises from defects in basic processes associated with metazoan multicellularity.

Citations

265 citations in Web of Science®
273 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

3 downloads since deposited on 20 Jan 2011
0 downloads since 12 months

Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Evolutionary Biology and Environmental Studies
DDC:570 Life sciences; biology
590 Animals (Zoology)
Language:English
Date:August 2010
Deposited On:20 Jan 2011 17:59
Last Modified:27 Nov 2013 20:30
Publisher:Nature Publishing Group
ISSN:0028-0836
Funders:Australian Research Council ; US Department of Energy Joint Genome Institute ; NSF ; NIH/NHGRI ; University of Queensland ; Sars International Centre for Marine Molecular Biology ; DFG ; ANR ; CNRS ; Gordon and Betty Moore Foundation ; Office of Science o
Publisher DOI:10.1038/nature09201
Other Identification Number:ISI:000280562500031

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page