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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-42313

Spahn, D R (2010). Anemia and patient blood management in hip and knee surgery: a systematic review of the literature. Anesthesiology, 113(2):482-495.

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Abstract

A systematic search was conducted to determine the characteristics of perioperative anemia, its association with clinical outcomes, and the effects of patient blood management interventions on these outcomes in patients undergoing major orthopedic surgery. In patients undergoing total hip or knee arthroplasty and hip fracture surgery, preoperative anemia was highly prevalent, ranging from 24 +/- 9% to 44 +/- 9%, respectively. Postoperative anemia was even more prevalent (51% and 87 +/- 10%, respectively). Perioperative anemia was associated with a blood transfusion rate of 45 +/- 25% and 44 +/- 15%, postoperative infections, poorer physical functioning and recovery, and increased length of hospital stay and mortality. Treatment of preoperative anemia with iron, with or without erythropoietin, and perioperative cell salvage decreased the need for blood transfusion and may contribute to improved patient outcomes. High-impact prospective studies are necessary to confirm these findings and establish firm clinical guidelines.

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Anesthesiology
DDC:610 Medicine & health
Language:English
Date:2010
Deposited On:14 Jan 2011 15:16
Last Modified:03 Dec 2013 16:58
Publisher:Lippincott Wiliams & Wilkins
ISSN:0003-3022
Publisher DOI:10.1097/ALN.0b013e3181e08e97
PubMed ID:20613475
Citations:Web of Science®. Times Cited: 85
Google Scholar™
Scopus®. Citation Count: 113

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