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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-42327

Beck-Schimmer, B; Bonvini, J M (2011). Bronchoaspiration: incidence, consequences and management. European Journal of Anaesthesiology, 28(2):78-84.

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Abstract

Aspiration is defined as the inhalation of oropharyngeal or gastric contents into the lower respiratory tract. Upon injury, epithelial cells and alveolar macrophages secrete chemical mediators, attracting and activating neutrophils, which in turn release proteases and reactive oxygen species, degrading the alveolocapillary unit. Aspiration can lead to a range of diseases such as infectious pneumonia, chemical pneumonitis or respiratory distress syndrome with significant morbidity and mortality. It occurs in approximately 3-10 per 10 000 operations with an increased incidence in obstetric and paediatric anaesthesia. Patients are most at risk during induction of anaesthesia and extubation, in particular in emergency situations. The likelihood of significant aspiration can be reduced by fasting, pharmacological intervention and correct anaesthetic management using a rapid sequence induction. Treatment of acid aspiration is by suctioning after witnessed aspiration; antibiotics are indicated in patients with aspiration pneumonia only. Steroids are not proven to improve outcome or reduce mortality. Patients with acute lung injury requiring mechanical ventilation should be ventilated using lung protective strategies with low tidal volumes and low plateau pressure values, attempting to limit peak lung distension and end-expiratory collapse.

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Anesthesiology
DDC:610 Medicine & health
Uncontrolled Keywords:Review
Language:English
Date:2011
Deposited On:14 Jan 2012 15:08
Last Modified:29 Nov 2013 12:51
Publisher:Lippincott Wiliams & Wilkins
ISSN:0265-0215
Publisher DOI:10.1097/EJA.0b013e32834205a8
PubMed ID:21157355
Citations:Web of Science®. Times Cited: 6
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