Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-4235
Pantel, G; Probst, R; Podvinec, M; Gürtler, N (2009). Hearing loss and fluctuating hearing levels in X-linked hypophosphataemic osteomalacia. Journal of Laryngology and Otology, 123(1):136-140.
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Background and objective:X-linked hypophosphataemic osteomalacia is the most common of the genetically determined forms of osteomalacia. The occurrence of hearing loss in X-linked hypophosphataemic osteomalacia has been known since 1984. However, observations on the progression of such hearing loss, and suggestions regarding possible therapy, have not previously been published.Methods:Case report of a patient with X-linked hypophosphataemic osteomalacia and hearing loss, with three years' audiological follow up, description of empirical therapy and literature review.Results:The patient presented with fluctuating hearing. An audiogram showed mild to severe sensorineural hearing loss mainly in the low and high frequencies. A temporary improvement of 20-40 dB after steroid therapy was observed. Four weeks later, hearing had deteriorated again, mainly in the low frequencies. After one year of fluctuating hearing levels, stabilisation occurred.Conclusions:In X-linked hypophosphataemic osteomalacia, hearing loss occurs predominantly in the low and high frequencies. The hearing loss type and progression pattern point to an endolymphatic hydrops as the pathogenetic mechanism. Steroid therapy may be of some benefit.
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|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Clinic for Otorhinolaryngology|
|DDC:||610 Medicine & health|
|Deposited On:||29 Oct 2008 12:52|
|Last Modified:||07 Dec 2013 01:14|
|Publisher:||Cambridge University Press|
|Additional Information:||Copyright: Cambridge University Press|
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