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Peripherally applied Aβ-containing inoculates induce cerebral β-amyloidosis


Eisele, Y S; Obermüller, U; Heilbronner, G; Baumann, F; Kaeser, S A; Wolburg, H; Walker, L C; Staufenbiel, M; Heikenwalder, M; Jucker, M (2010). Peripherally applied Aβ-containing inoculates induce cerebral β-amyloidosis. Science, 330(6006):980-982.

Abstract

The intracerebral injection of β-amyloid-containing brain extracts can induce cerebral β-amyloidosis and associated pathologies in susceptible hosts. We found that intraperitoneal inoculation with β-amyloid-rich extracts induced β-amyloidosis in the brains of β-amyloid precursor protein transgenic mice after prolonged incubation times.

The intracerebral injection of β-amyloid-containing brain extracts can induce cerebral β-amyloidosis and associated pathologies in susceptible hosts. We found that intraperitoneal inoculation with β-amyloid-rich extracts induced β-amyloidosis in the brains of β-amyloid precursor protein transgenic mice after prolonged incubation times.

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213 citations in Web of Science®
226 citations in Scopus®
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Additional indexing

Other titles:Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis
Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Neuropathology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2010
Deposited On:19 Jan 2011 13:50
Last Modified:05 Apr 2016 14:36
Publisher:American Association for the Advancement of Science (AAAS)
ISSN:0036-8075
Additional Information:Comment in: Science. 2010 Nov 12;330(6006):918-9.
Publisher DOI:10.1126/science.1194516
PubMed ID:20966215
Permanent URL: http://doi.org/10.5167/uzh-42631

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