Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-42988
Schwarz, F; Jung, R E; Fienitz, T; Wieland, M; Becker, J; Sager, M (2010). Impact of guided bone regeneration and defect dimension on wound healing at chemically modified hydrophilic titanium implant surfaces: an experimental study in dogs. Journal of Clinical Periodontology, 37(5):474-485.
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OBJECTIVES: The aim of the present study was to evaluate the impact of guided bone regeneration and defect dimension on wound healing at chemically modified titanium implant surfaces (modSLA).
MATERIALS AND METHODS: ModSLA implants were placed at chronic-type lateral ridge defects of different heights (H1-H4: 2, 4, 6 and 8 mm) and randomly allocated to either (a) GBR (polyethylene glycol membrane + biphasic calcium phosphate) or (b) untreated control. At 2 and 8 weeks (n=6 dogs each), dissected blocks were processed for histomorphometrical analysis [e.g., percentage linear fill (PLF), regenerated area (RA)].
RESULTS: At 8 weeks, both groups revealed comparable mean PLF (%) [Control: H1 (26.1 +/- 5.8)-H4 (60.4 +/- 11.8); GBR: H1 (8.3 +/- 5.3)-H4 (50.7 +/- 23.1)] and RA (mm(2)) [Control: H1 (2.5 +/- 0.4)-H4 (7.4 +/- 4.1); GBR: H1 (1.8 +/- 1.0)-H4 (10.8 +/- 5.9)] values. A significant difference was observed for the mean PLF values at H1 defects.
CONCLUSION: It was concluded that (i) modSLA titanium implants supported bone regeneration and osseointegration at H1-H4 defects and (ii) the present GBR procedure did not seem to improve the outcome of vertical bone regeneration, but tended to increase the mean RA values.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > Center for Dental Medicine > Clinic for Fixed and Removable Prosthodontics|
|DDC:||610 Medicine & health|
|Deposited On:||23 Jan 2011 09:17|
|Last Modified:||23 Nov 2012 14:03|
|Additional Information:||The definitive version is available at www.blackwell-synergy.com|
|WoS Citation Count:||4|
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