UZH-Logo

Maintenance Infos

Unlocking the mystery of periodontal regeneration - different tissues, different phenotypes


Thoma, D S; Cochran, D L (2010). Unlocking the mystery of periodontal regeneration - different tissues, different phenotypes. Journal de Parodontologie et d'Implantologie Orale, 29(1):23-60.

Abstract

Different factors and pathways are involved in the regeneration of the tooth-supporting structures based on the fact that hard connective tissue (bone/cementum) and soft connective tissue (periodontal ligament) have to be restored. Several approaches have been taken to regenerate periodontal tissues. Among these, it has been shown that the incorporation of biologic mediators can specifically stimulate and coordinate regenerative processes. Various procedures have focused on the use of biologic mediators and include the application of: i) a single factor, ii) a cocktail of factors, iii) cell-based therapy, and iv) tissue engineering principles. The use of single factors shows variation in regenerating tooth-supporting structures depending on the applied factor. The application of a combination of factors, either being a combination of current single products, or an existing product containing a combination of proteins, appears to be the most promising approach presently to stimulate both the soft and hard connective tissues. The biologic factors are generally dissolved in a liquid and must be combined with a carrier. In some cases, the carrier is not space making and the factor plus carrier must be applied with a space-maintaining device. Cell-based therapies open the door towards the use of “smart” technologies for the regeneration of the periodontium. However, a review of the literature with respect to tissue engineering where three components (biologic factor, carrier, cells) are used for regenerating tissue revealed few published papers for the oral cavity. In conclusion, the periodontium is a complex heterogeneous tissue made up of both soft and hard connective tissues. While current therapeutic efforts have focused on various approaches to stimulate periodontal regeneration, it is clear that there is a need for further developments and consequently, significant improvements in periodontal regenerative therapy.

Different factors and pathways are involved in the regeneration of the tooth-supporting structures based on the fact that hard connective tissue (bone/cementum) and soft connective tissue (periodontal ligament) have to be restored. Several approaches have been taken to regenerate periodontal tissues. Among these, it has been shown that the incorporation of biologic mediators can specifically stimulate and coordinate regenerative processes. Various procedures have focused on the use of biologic mediators and include the application of: i) a single factor, ii) a cocktail of factors, iii) cell-based therapy, and iv) tissue engineering principles. The use of single factors shows variation in regenerating tooth-supporting structures depending on the applied factor. The application of a combination of factors, either being a combination of current single products, or an existing product containing a combination of proteins, appears to be the most promising approach presently to stimulate both the soft and hard connective tissues. The biologic factors are generally dissolved in a liquid and must be combined with a carrier. In some cases, the carrier is not space making and the factor plus carrier must be applied with a space-maintaining device. Cell-based therapies open the door towards the use of “smart” technologies for the regeneration of the periodontium. However, a review of the literature with respect to tissue engineering where three components (biologic factor, carrier, cells) are used for regenerating tissue revealed few published papers for the oral cavity. In conclusion, the periodontium is a complex heterogeneous tissue made up of both soft and hard connective tissues. While current therapeutic efforts have focused on various approaches to stimulate periodontal regeneration, it is clear that there is a need for further developments and consequently, significant improvements in periodontal regenerative therapy.

Downloads

1 download since deposited on 22 Jan 2011
0 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Center for Dental Medicine > Clinic for Fixed and Removable Prosthodontics
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2010
Deposited On:22 Jan 2011 17:38
Last Modified:05 Apr 2016 14:37
Publisher:Groupe CdP
ISSN:1256-6128
Related URLs:http://www.editionscdp.fr/decouvrir-jpio.html (Publisher)
Permanent URL: https://doi.org/10.5167/uzh-42995

Download

[img]
Content: Accepted Version
Filetype: PDF - Repository staff only
Size: 1MB

TrendTerms

TrendTerms displays relevant terms of the abstract of this publication and related documents on a map. The terms and their relations were extracted from ZORA using word statistics. Their timelines are taken from ZORA as well. The bubble size of a term is proportional to the number of documents where the term occurs. Red, orange, yellow and green colors are used for terms that occur in the current document; red indicates high interlinkedness of a term with other terms, orange, yellow and green decreasing interlinkedness. Blue is used for terms that have a relation with the terms in this document, but occur in other documents.
You can navigate and zoom the map. Mouse-hovering a term displays its timeline, clicking it yields the associated documents.

Author Collaborations