Quick Search:

uzh logo
Browse by:

Zurich Open Repository and Archive

Maintenance: Tuesday, 5.7.2016, 07:00-08:00

Maintenance work on ZORA and JDB on Tuesday, 5th July, 07h00-08h00. During this time there will be a brief unavailability for about 1 hour. Please be patient.

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-43160

Janus, C; Welzl, H (2010). Mouse models of neurodegenerative diseases: criteria and general methodology. In: Proetzel, G. Mouse Models for Drug Discovery : Methods and Protocols. United States: Springer, 323-345.

Accepted Version
View at publisher
[img] PDF - Registered users only


The major symptom of Alzheimer's disease is rapidly progressing dementia, coinciding with the formation of amyloid and tau deposits in the central nervous system, and neuronal death. At present familial cases of dementias provide the most promising foundation for modelling neurodegeneration. We describe the mnemonic and other major behavioral symptoms of tauopathies, briefly outline the genetics underlying familiar cases and discuss the arising implications for modelling the disease in mostly transgenic mouse lines. We then depict to what degree the most recent mouse models replicate pathological and cognitive characteristics observed in patients.There is no universally valid behavioral test battery to evaluate mouse models. The selection of individual tests depends on the behavioral and/or memory system in focus, the type of a model and how well it replicates the pathology of a disease and the amount of control over the genetic background of the mouse model. However it is possible to provide guidelines and criteria for modelling the neurodegeneration, setting up the experiments and choosing relevant tests. One should not adopt a "one (trans)gene, one disease" interpretation, but should try to understand how the mouse genome copes with the protein expression of the transgene in question. Further, it is not possible to recommend some mouse models over others since each model is valuable within its own constraints, and the way experiments are performed often reflects the idiosyncratic reality of specific laboratories. Our purpose is to improve bridging molecular and behavioural approaches in translational research.


8 citations in Web of Science®
6 citations in Scopus®
Google Scholar™



133 downloads since deposited on 25 Jan 2011
20 downloads since 12 months

Detailed statistics

Additional indexing

Item Type:Book Section, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Anatomy
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Deposited On:25 Jan 2011 14:35
Last Modified:05 Apr 2016 14:38
Series Name:Methods in Molecular Biology
Additional Information:The original publication is available at www.springerlink.com
Publisher DOI:10.1007/978-1-60761-058-8_19
PubMed ID:20012407

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page