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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-43437

Ozbalkan, Z; Efe, C; Cesur, M; Ertek, S; Nasiroglu, N; Berneis, K; Rizzo, M (2010). An update on the relationships between rheumatoid arthritis and atherosclerosis. Atherosclerosis, 212(2):377-382.

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Abstract

Rheumatoid arthritis is a chronic inflammatory disease. Cardiovascular events are the most important cause of mortality and morbidity in patients with rheumatoid arthritis. Beyond the traditional cardiovascular risk factors, chronic systemic inflammation has been shown to be a crucial factor in atherosclerosis development and progression from endothelial dysfunction to plaque rupture and thrombosis. Many studies have shown that atherosclerosis is not a passive event like accumulation of lipids in the vessel walls; by contrast, it represents an active inflammation of the vessels. Inflammatory cells such as macrophages, monocytes and T cells play important roles in the development of both rheumatoid arthritis and atherosclerosis. In this article we analyse the relationships between rheumatoid arthritis and atherosclerosis.

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Endocrinology and Diabetology
DDC:610 Medicine & health
Language:English
Date:2010
Deposited On:31 Jan 2011 17:54
Last Modified:07 Jan 2014 21:28
Publisher:Elsevier
ISSN:0021-9150
Publisher DOI:10.1016/j.atherosclerosis.2010.03.035
PubMed ID:20430394
Citations:Web of Science®. Times Cited: 17
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Scopus®. Citation Count: 22

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