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Zhu, P; Zhang, K; Wang, Z; Liu, Y; Liu, X; Wu, Z; McDonald, S A; Marone, F; Stampanoni, M (2010). Low-dose, simple, and fast grating-based X-ray phase-contrast imaging. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 107(31):13576-13581.

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Phase sensitive X-ray imaging methods can provide substantially increased contrast over conventional absorption-based imaging and therefore new and otherwise inaccessible information. The use of gratings as optical elements in hard X-ray phase imaging overcomes some of the problems that have impaired the wider use of phase contrast in X-ray radiography and tomography. So far, to separate the phase information from other contributions detected with a grating interferometer, a phase-stepping approach has been considered, which implies the acquisition of multiple radiographic projections. Here we present an innovative, highly sensitive X-ray tomographic phase-contrast imaging approach based on grating interferometry, which extracts the phase-contrast signal without the need of phase stepping. Compared to the existing phase-stepping approach, the main advantages of this new method dubbed "reverse projection" are not only the significantly reduced delivered dose, without the degradation of the image quality, but also the much higher efficiency. The new technique sets the prerequisites for future fast and low-dose phase-contrast imaging methods, fundamental for imaging biological specimens and in vivo studies.


101 citations in Web of Science®
110 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Biomedical Engineering
Dewey Decimal Classification:170 Ethics
610 Medicine & health
Deposited On:26 Jan 2011 12:49
Last Modified:05 Apr 2016 14:39
Publisher:National Academy of Sciences
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:10.1073/pnas.1003198107
PubMed ID:20643971

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