Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-43541
Sotiriou, G A; Sannomiya, T; Teleki, A; Krumeich, F; Vörös, J; Pratsinis, S E (2010). Non-toxic dry-coated nanosilver for plasmonic biosensors. Advanced Functional Materials, 20(24):4250-4257.
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The plasmonic properties of noble metals facilitate their use for in vivo bio-applications such as targeted drug delivery and cancer cell therapy. Nanosilver is best suited for such applications as it has the lowest plasmonic losses among all such materials in the UV-visible spectrum. Its toxicity, however, can destroy surrounding healthy tissues and thus, hinders its safe use. Here, that toxicity against a model biological system (Escherichia coli) is “cured” or blocked by coating nanosilver hermetically with a about 2 nm thin SiO2 layer in one-step by a scalable flame aerosol method followed by swirl injection of a silica precursor vapor (hexamethyldisiloxane) without reducing the plasmonic performance of the enclosed or encapsulated silver nanoparticles (20–40 nm in diameter as determined by X-ray diffraction and microscopy). This creates the opportunity to safely use powerful nanosilver for intracellular bio-applications. The label-free biosensing and surface bio-functionalization of these ready-to-use, non-toxic (benign) Ag nanoparticles is presented by measuring the adsorption of bovine serum albumin (BSA) in a model sensing experiment. Furthermore, the silica coating around nanosilver prevents its agglomeration or flocculation (as determined by thermal annealing, optical absorption spectroscopy and microscopy) and thus, enhances its biosensitivity, including bioimaging as determined by dark field illumination.
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|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > Institute of Biomedical Engineering|
610 Medicine & health
|Deposited On:||26 Jan 2011 14:57|
|Last Modified:||27 Nov 2013 17:09|
|Free access at:||Related URL. An embargo period may apply.|
|Related URLs:||http://onlinelibrary.wiley.com/doi/10.1002/adfm.201000985/abstract (Publisher)|
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