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Weder, G; Blondiaux, N; Giazzon, M; Matthey, N; Klein, M; Pugin, R; Heinzelmann, H; Liley, M (2010). Use of force spectroscopy to investigate the adhesion of living adherent cells. Langmuir, 26(11):8180-8186.

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The use of force spectroscopy to study the adhesion of living fibroblasts to their culture substrate was investigated. Both primary fibroblasts (PEMF) and a continuous cell line (3T3) were studied on quartz surfaces. Using a fibronectin-coated AFM cantilever, it was possible to detach a large proportion of the 3T3 cells from the quartz surfaces. Their adhesion to the quartz surface and the effects of topography on this adhesion could be quantified. Three parameters characteristic of the adhesion were measured: the maximum force of detachment, the work of adhesion, and the distance of detachment. Few PEMF cells were detached under the same experimental conditions. The potential and limitations of this method in measuring cell/surface interactions for adherent cells are discussed.


15 citations in Web of Science®
15 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Biomedical Engineering
Dewey Decimal Classification:170 Ethics
610 Medicine & health
Deposited On:26 Jan 2011 13:40
Last Modified:05 Apr 2016 14:39
Publisher:American Chemical Society
Publisher DOI:10.1021/la904526u
Related URLs:http://pubs.acs.org/doi/abs/10.1021/la904526u (Publisher)
PubMed ID:20146500

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