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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-43616

Rüsch, N; Bracht, T; Kreher, B W; Schnell, S; Glauche, V; Il'yasov, K A; Ebert, D; Lieb, K; Hennig, J; Saur, D; Tebartz van Elst, L (2010). Reduced interhemispheric structural connectivity between anterior cingulate cortices in borderline personality disorder. Psychiatry Research, 181(2):151-154.

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Functional and structural alterations of the anterior cingulate cortex (ACC), a key region for emotional and cognitive processing, are associated with borderline personality disorder (BPD). However, the interhemispheric structural connectivity between the left and right ACC and between other prefrontal regions in this condition is unknown. We acquired diffusion-tensor imaging data from 20 healthy women and 19 women with BPD and comorbid attention-deficit hyperactivity disorder (ADHD). Interhemispheric structural connectivity between both sides of the ACC, dorsolateral prefrontal cortices and medial orbitofrontal cortices was assessed by a novel probabilistic diffusion tensor-based fiber tracking method. In the BPD group as compared with healthy controls, we found decreased interhemispheric structural connectivity between both ACCs in fiber tracts that pass through the anterior corpus callosum and connect dorsal areas of the ACCs. Decreased interhemispheric structural connectivity between both ACCs may be a structural correlate of BPD.
Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.


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Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Psychiatric University Hospital Zurich > Clinic for Clinical and Social Psychiatry Zurich West (former)
Dewey Decimal Classification:610 Medicine & health
Deposited On:31 Jan 2011 15:52
Last Modified:05 Apr 2016 14:39
Publisher DOI:10.1016/j.pscychresns.2009.08.004
PubMed ID:20079614

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