Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-43616
Rüsch, N; Bracht, T; Kreher, B W; Schnell, S; Glauche, V; Il'yasov, K A; Ebert, D; Lieb, K; Hennig, J; Saur, D; Tebartz van Elst, L (2010). Reduced interhemispheric structural connectivity between anterior cingulate cortices in borderline personality disorder. Psychiatry Research, 181(2):151-154.
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Functional and structural alterations of the anterior cingulate cortex (ACC), a key region for emotional and cognitive processing, are associated with borderline personality disorder (BPD). However, the interhemispheric structural connectivity between the left and right ACC and between other prefrontal regions in this condition is unknown. We acquired diffusion-tensor imaging data from 20 healthy women and 19 women with BPD and comorbid attention-deficit hyperactivity disorder (ADHD). Interhemispheric structural connectivity between both sides of the ACC, dorsolateral prefrontal cortices and medial orbitofrontal cortices was assessed by a novel probabilistic diffusion tensor-based fiber tracking method. In the BPD group as compared with healthy controls, we found decreased interhemispheric structural connectivity between both ACCs in fiber tracts that pass through the anterior corpus callosum and connect dorsal areas of the ACCs. Decreased interhemispheric structural connectivity between both ACCs may be a structural correlate of BPD.
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|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > Psychiatric University Hospital Zurich > Clinic for Clinical and Social Psychiatry Zurich West|
|DDC:||610 Medicine & health|
|Deposited On:||31 Jan 2011 16:52|
|Last Modified:||01 Jan 2013 21:39|
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