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Disulfiram, an option for the treatment of pathological gambling?


Mutschler, J; Buhler, M; Grosshans, M; Diehl, A; Mann, K; Kiefer, F (2010). Disulfiram, an option for the treatment of pathological gambling? Alcohol and Alcoholism, 45(2):214-216.

Abstract

AIM: Pathological gambling and comorbid alcohol dependence often occur in combination. Disulfiram is one of the proven drugs for alcohol dependence. In addition to its inhibiting acetaldehyde dehydrogenase, disulfiram inhibits dopamine beta-hydroxylase and may thereby increase dopamine and decrease norepinephrine cerebral concentrations. Because there may be common neurochemical substrates and neuronal circuits for pathological gambling and addiction, we wished to explore the effect of disulfiram in gambling.

METHOD: We describe the outcome of a patient with alcohol dependence and pathological gambling treated with disulfiram D.

RESULTS: During treatment with disulfiram, the patient reported that his desire to gamble disappeared entirely. Follow-up indicated that he has not gambled for >12 months.

CONCLUSIONS: Although uncontrolled case observations should be interpreted with caution, disulfiram deserves further investigation in pathological gambling.

AIM: Pathological gambling and comorbid alcohol dependence often occur in combination. Disulfiram is one of the proven drugs for alcohol dependence. In addition to its inhibiting acetaldehyde dehydrogenase, disulfiram inhibits dopamine beta-hydroxylase and may thereby increase dopamine and decrease norepinephrine cerebral concentrations. Because there may be common neurochemical substrates and neuronal circuits for pathological gambling and addiction, we wished to explore the effect of disulfiram in gambling.

METHOD: We describe the outcome of a patient with alcohol dependence and pathological gambling treated with disulfiram D.

RESULTS: During treatment with disulfiram, the patient reported that his desire to gamble disappeared entirely. Follow-up indicated that he has not gambled for >12 months.

CONCLUSIONS: Although uncontrolled case observations should be interpreted with caution, disulfiram deserves further investigation in pathological gambling.

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13 citations in Web of Science®
16 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Psychiatric University Hospital Zurich > Clinic for Clinical and Social Psychiatry Zurich West (former)
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2010
Deposited On:31 Jan 2011 14:33
Last Modified:05 Apr 2016 14:40
Publisher:Oxford University Press
ISSN:0735-0414
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:10.1093/alcalc/agp093
PubMed ID:20083479
Permanent URL: http://doi.org/10.5167/uzh-43671

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