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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-43763

Wielinga, P Y; Löwenstein, C; Muff, S; Munz, M; Woods, S C; Lutz, T A (2010). Central amylin acts as an adiposity signal to control body weight and energy expenditure. Physiology & Behavior, 101(1):45-52.

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Abstract

The pancreatic B-cell hormone amylin has been proposed to be both a satiation signal and an adiposity signal. The effects of peripheral amylin on energy balance are well investigated, but the effects of central amylin are less clear. We determined the effects of low doses of amylin administered into the 3rd cerebral ventricle (i3vt) on food intake, body weight and other indices of energy balance. Amylin (2 pmol/h) significantly lowered body weight compared to saline after 2 weeks of infusion, independent of whether prior body weight was decreased by fasting, increased by voluntary overfeeding or unmanipulated. A bolus injection of amylin (10 pmol, i3vt) increased energy expenditure and body temperature, whereas chronic i3vt amylin infusion had no effect on energy expenditure above that of control rats even though body temperature was increased. Chronic amylin also reduced RQ, implying a preferential oxidation of fat. Overall, the data provide new evidence that amylin is an adiposity signal that acts within the brain, and informing the brain about the status of peripheral energy stores.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Center for Integrative Human Physiology
05 Vetsuisse Faculty > Institute of Veterinary Physiology
DDC:570 Life sciences; biology
610 Medicine & health
Date:2010
Deposited On:27 Jan 2011 17:26
Last Modified:27 Nov 2013 21:49
Publisher:Elsevier
ISSN:0031-9384
Publisher DOI:10.1016/j.physbeh.2010.04.012
PubMed ID:20416330
Citations:Web of Science®. Times Cited: 18
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