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Reduced amygdala activity during aversive conditioning in human narcolepsy


Ponz, A; Khatami, R; Poryazova, R; Werth, E; Boesiger, P; Schwartz, S; Bassetti, C L (2010). Reduced amygdala activity during aversive conditioning in human narcolepsy. Annals of Neurology, 67(3):394-398.

Abstract

Narcolepsy with cataplexy is a sleep-wake disorder caused by a loss of hypothalamic hypocretins. Here we assessed the time course of amygdala activation during aversive conditioning in unmedicated patients with narcolepsy. Unlike healthy matched control subjects, narcolepsy patients had no enhancement of amygdala response to conditioned stimuli and no increase in functional coupling between the amygdala and medial prefrontal cortex. These findings suggest that human narcolepsy is accompanied by abnormal emotional learning, and that, in line with animal data, the hypocretin system and the amygdala are involved in this process.

Narcolepsy with cataplexy is a sleep-wake disorder caused by a loss of hypothalamic hypocretins. Here we assessed the time course of amygdala activation during aversive conditioning in unmedicated patients with narcolepsy. Unlike healthy matched control subjects, narcolepsy patients had no enhancement of amygdala response to conditioned stimuli and no increase in functional coupling between the amygdala and medial prefrontal cortex. These findings suggest that human narcolepsy is accompanied by abnormal emotional learning, and that, in line with animal data, the hypocretin system and the amygdala are involved in this process.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurology
04 Faculty of Medicine > Institute of Biomedical Engineering
Dewey Decimal Classification:170 Ethics
610 Medicine & health
Language:English
Date:2010
Deposited On:28 Jan 2011 16:55
Last Modified:05 Apr 2016 14:40
Publisher:Wiley-Blackwell
ISSN:0364-5134
Publisher DOI:10.1002/ana.21881
PubMed ID:20373351
Permanent URL: http://doi.org/10.5167/uzh-43794

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