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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-43794

Ponz, A; Khatami, R; Poryazova, R; Werth, E; Boesiger, P; Schwartz, S; Bassetti, C L (2010). Reduced amygdala activity during aversive conditioning in human narcolepsy. Annals of Neurology, 67(3):394-398.

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Narcolepsy with cataplexy is a sleep-wake disorder caused by a loss of hypothalamic hypocretins. Here we assessed the time course of amygdala activation during aversive conditioning in unmedicated patients with narcolepsy. Unlike healthy matched control subjects, narcolepsy patients had no enhancement of amygdala response to conditioned stimuli and no increase in functional coupling between the amygdala and medial prefrontal cortex. These findings suggest that human narcolepsy is accompanied by abnormal emotional learning, and that, in line with animal data, the hypocretin system and the amygdala are involved in this process.


28 citations in Web of Science®
32 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurology
04 Faculty of Medicine > Institute of Biomedical Engineering
Dewey Decimal Classification:170 Ethics
610 Medicine & health
Deposited On:28 Jan 2011 16:55
Last Modified:05 Apr 2016 14:40
Publisher DOI:10.1002/ana.21881
PubMed ID:20373351

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