Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-43794
Ponz, A; Khatami, R; Poryazova, R; Werth, E; Boesiger, P; Schwartz, S; Bassetti, C L (2010). Reduced amygdala activity during aversive conditioning in human narcolepsy. Annals of Neurology, 67(3):394-398.
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Narcolepsy with cataplexy is a sleep-wake disorder caused by a loss of hypothalamic hypocretins. Here we assessed the time course of amygdala activation during aversive conditioning in unmedicated patients with narcolepsy. Unlike healthy matched control subjects, narcolepsy patients had no enhancement of amygdala response to conditioned stimuli and no increase in functional coupling between the amygdala and medial prefrontal cortex. These findings suggest that human narcolepsy is accompanied by abnormal emotional learning, and that, in line with animal data, the hypocretin system and the amygdala are involved in this process.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurology|
04 Faculty of Medicine > Institute of Biomedical Engineering
610 Medicine & health
|Deposited On:||28 Jan 2011 16:55|
|Last Modified:||27 Nov 2013 19:31|
|Citations:||Web of Science®. Times Cited: 18|
Scopus®. Citation Count: 20
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