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Systemic sclerosis-associated interstitial lung disease: Lessons from clinical trials, outcome measures, and future study design


Khanna, D; Seibold, J R; Wells, A; Distler, O; Allanore, Y; Denton, C; Furst, D E (2010). Systemic sclerosis-associated interstitial lung disease: Lessons from clinical trials, outcome measures, and future study design. Current Rheumatology Review, 6(2):138-144.

Abstract

Pulmonary involvement including interstitial lung disease (ILD) is the leading cause of mortality in patients with systemic sclerosis (scleroderma; SSc). This article reviews the current evidence based medicine regarding available therapies for SSc-ILD ; discusses the lessons learned from recent SSc-ILD randomized controlled trials (RCTs); and proposes outcome measures and recommendations for design of future RCTs for SSc-ILD.

Pulmonary involvement including interstitial lung disease (ILD) is the leading cause of mortality in patients with systemic sclerosis (scleroderma; SSc). This article reviews the current evidence based medicine regarding available therapies for SSc-ILD ; discusses the lessons learned from recent SSc-ILD randomized controlled trials (RCTs); and proposes outcome measures and recommendations for design of future RCTs for SSc-ILD.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Rheumatology Clinic and Institute of Physical Medicine
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2010
Deposited On:02 Feb 2011 15:35
Last Modified:05 Apr 2016 14:40
Publisher:Bentham Science
ISSN:1573-3971
Publisher DOI:10.2174/157339710791330768
PubMed ID:20676227

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