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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-44014

Pagani, L; Eckert, A; Brown, S A (2011). Studying human circadian behaviour using peripheral cells. In: Clelland, J D. Genomics, Proteomics, and the Nervous System. New York, 279-302. ISBN 978-1-441-97196-8 (hbk.) ; 978-1-441-97197-5 (ebook).

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Complex behaviours are the product of intercellular signalling events, but their intracellular effectors are present in most cell types. The best-studied example of such architecture is the circadian clock, which directs all diurnal behaviour and physiology, and whose central mechanism is present in most body cells. We present below a method to look at its properties via transcriptional reporters virally delivered to primary cells. By studying primary fibroblasts cultivated from skin biopsies in different human subjects, we have been able to analyse the molecular underpinnings of variance in human daily behaviour. Similar methodologies could be applied to other signalling pathways.

Item Type:Book Section, not refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
DDC:570 Life sciences; biology
610 Medicine & health
Deposited On:03 Feb 2011 18:13
Last Modified:05 Jan 2014 06:56
Series Name:Advances in Neurobiology
ISBN:978-1-441-97196-8 (hbk.) ; 978-1-441-97197-5 (ebook)
Publisher DOI:10.1007/978-1-4419-7197-5_11
Citations:Web of Science®
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