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Understanding protein adsorption phenomena at solid surfaces


Rabe, Michael; Verdes, Dorinel; Seeger, Stefan (2011). Understanding protein adsorption phenomena at solid surfaces. Advances in Colloid and Interface Science, 162(1-2):87-106.

Abstract

Protein adsorption at solid surfaces plays a key role in many natural processes and has therefore promoted a widespread interest in many research areas. Despite considerable progress in this field there are still widely differing and even contradictive opinions on how to
explain the frequently observed phenomena such as structural rearrangements, cooperative adsorption, overshooting adsorption kinetics, or protein aggregation. In this review recent achievements and new perspectives on protein adsorption processes are comprehensively
discussed. The main focus is put on commonly postulated mechanistic aspects and their translation into mathematical concepts and model descriptions. Relevant experimental and
computational strategies to practically approach the field of protein adsorption mechanisms and their impact on current successes are outlined.

Protein adsorption at solid surfaces plays a key role in many natural processes and has therefore promoted a widespread interest in many research areas. Despite considerable progress in this field there are still widely differing and even contradictive opinions on how to
explain the frequently observed phenomena such as structural rearrangements, cooperative adsorption, overshooting adsorption kinetics, or protein aggregation. In this review recent achievements and new perspectives on protein adsorption processes are comprehensively
discussed. The main focus is put on commonly postulated mechanistic aspects and their translation into mathematical concepts and model descriptions. Relevant experimental and
computational strategies to practically approach the field of protein adsorption mechanisms and their impact on current successes are outlined.

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346 citations in Web of Science®
360 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Language:English
Date:2011
Deposited On:16 Feb 2011 14:29
Last Modified:05 Apr 2016 14:41
Publisher:Elsevier
ISSN:0001-8686
Funders:c.henningsen@pci.uzh.ch
Publisher DOI:10.1016/j.cis.2010.12.007
PubMed ID:21295764
Permanent URL: http://doi.org/10.5167/uzh-44154

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