Quick Search:

uzh logo
Browse by:

Zurich Open Repository and Archive

Maintenance: Tuesday, July the 26th 2016, 07:00-10:00

ZORA's new graphical user interface will be relaunched (For further infos watch out slideshow ZORA: Neues Look & Feel). There will be short interrupts on ZORA Service between 07:00am and 10:00 am. Please be patient.

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-44574

Monoranu, C M; Grünblatt, E; Bartl, J; Meyer, A; Apfelbacher, M; Keller, D; Michel, T M; Al-Saraj, S; Schmitt, A; Falkai, P; Roggendorf, W; Deckert, J; Ferrer, I; Riederer, P (2011). Methyl- and acetyltransferases are stable epigenetic markers postmortem. Cell and Tissue Banking, 12(4):289-297.

[img] PDF - Registered users only
View at publisher


Postmortem brain tissue has been reported to be suitable to delineate regional pattern of possible disturbances underlying epigenetic functionality. However, from many parameters that have been detected in postmortem brain regions it is noteworthy that an effect of postmortem interval (PMI), storage time and premortem parameters should not be underestimated. Our previous investigation revealed that tryptophan (TRP) levels in postmortem brain tissue is affected by PMI and storage time. Since, alteration in TRP levels are assumed to be due to protein degradation, we further investigated whether TRP correlates to variables such as RNA, proteins and DNA modulators. In addition, we aimed to elucidate whether established postmortem variables may influence epigenetic parameters. These were investigated in well characterized postmortem human brain tissue originating from the European Brain Bank consortium II (BNEII). We could confirm previous findings, in which some protein levels alter because of prolonged PMI. Similarly, we demonstrated an influence of increased storage period on TRP levels, which might indicate degradation of proteins. Still not all proteins degrade in a similar manner, therefore a specific analysis for the protein of interest would be recommended. We found that methyltransferase- and acetyltransferase-activities were relatively preserved with PMI and storage duration. In conclusion, preservation of acetyltransferase- and methyltransferase-activities provides possible evidence of stability for epigenetic studies using postmortem tissue.


3 citations in Web of Science®
5 citations in Scopus®
Google Scholar™



0 downloads since deposited on 04 Feb 2011
0 downloads since 12 months

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Center for Child and Adolescent Psychiatry
Dewey Decimal Classification:610 Medicine & health
Deposited On:04 Feb 2011 16:13
Last Modified:05 Apr 2016 14:43
Publisher DOI:10.1007/s10561-010-9199-z
PubMed ID:20652834

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page