Quick Search:

uzh logo
Browse by:

Zurich Open Repository and Archive

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-44577

Michel, T M; Camara, S; Tatschner, T; Frangou, S; Sheldrick, A J; Riederer, P; Grünblatt, E (2010). Increased xanthine oxidase in the thalamus and putamen in depression. World Journal of Biological Psychiatry, 11(2 Pt 2):314-320.

[img] PDF - Registered users only
View at publisher


A growing body of literature suggests persistent and selective structural changes in the cortico-limbic-thalamic-striatal system in patients with recurrent depressive disorder (DD). Oxidative stress is thought to play a key role in these processes. So far, the main scientific focus has been on antioxidant enzymes in this context. For the first time, this proof of concept study examines the activity of the free radicals producing the enzyme, xanthine oxidase (XO), directly in the cortico-limbic-thalamic-striatal system of patients with recurrent depression. The activity of XO was ascertained in the cortico-limbic-thalamic-striatal regions in post-mortem brain tissue of patients with recurrent depressive episodes and individuals without any neurological or psychiatric history (7/7). We measured the XO activity in following brain areas: hippocampus, regio entorhinalis, thalamus, putamen and caudate nucleus. In this study, we report a significant increase of XO activity in the thalamus and the putamen of patients with depression. Our findings contribute to the growing body of evidence suggesting that oxidative stress plays a pivotal role in certain brain areas in recurrent depressive disorder.


15 citations in Web of Science®
16 citations in Scopus®
Google Scholar™



0 downloads since deposited on 04 Feb 2011
0 downloads since 12 months

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Center for Child and Adolescent Psychiatry
Dewey Decimal Classification:610 Medicine & health
Date:March 2010
Deposited On:04 Feb 2011 16:03
Last Modified:05 Apr 2016 14:43
Publisher:Informa Healthcare
Publisher DOI:10.3109/15622970802123695
PubMed ID:20218795

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page