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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-44694

Belibasakis, G N; Emingil, G; Saygan, B; Turkoglu, O; Atilla, G; Bostanci, N (2011). Gene expression of transcription factor NFATc1 in periodontal diseases. APMIS: Acta Pathologica, Microbiologica et Immunologica Scandinavica, 119(3):167-172.

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Abstract

Belibasakis GN, Emingil G, Saygan B, Turkoglu O, Atilla G, Bostanci N. Gene expression of transcription factor NFATc1 in periodontal diseases. APMIS 2011; 119: 167-172. Periodontitis is a disease of infectious aetiology that causes inflammatory destruction of the tooth-supporting tissues. Activated T cells are central to the pathogenesis of the disease, by producing receptor activator of nuclear factor κB (NF-κB) ligand (RANKL) that stimulates bone resorption. Antigenic activation of T cells is regulated by the induction of transcription factor nuclear factor of activated T cells, cytoplasmic 1 (NFATc1). There is as yet no information on the potential involvement of NFATc1 in periodontal diseases. This study aimed to investigate NFATc1 gene expression levels in periodontal diseases, and analyse the potential correlation with RANKL expression and clinical periodontal parameters. In this cross-sectional study, gingival tissue biopsies were obtained from healthy (n = 10) and periodontally diseased (n = 58) sites. NFATc1 and RANKL gene expression levels in these samples were analysed by quantitative real-time polymerase chain reaction. Compared with healthy subjects, patients with gingivitis, chronic and aggressive periodontitis, exhibited higher NFATc1 expression, which proved to be statistically significant in the periodontitis groups. NFATc1 and RANKL expression levels strongly correlated with each other, and with clinical periodontal parameters. The increased expression of NFATc1 in periodontitis denotes a role for this transcription factor in the pathogenesis of the disease.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Center for Dental Medicine > Institute of Oral Biology
DDC:610 Medicine & health
Language:English
Date:2011
Deposited On:09 Mar 2011 09:40
Last Modified:01 Dec 2013 12:56
Publisher:Wiley-Blackwell
ISSN:0903-4641
Publisher DOI:10.1111/j.1600-0463.2010.02706.x
PubMed ID:21284733
Citations:Web of Science®. Times Cited: 2
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