Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-4478
Besler, C; Doerries, C; Giannotti, G; Luescher, T F; Landmesser, U (2008). Pharmacological approaches to improve endothelial repair mechanisms. Expert Review of Cardiovascular Therapy, 6(8):1071-1082.
- Registered users only
View at publisher
Endothelial injury is thought to play a pivotal role in the development and progression of vascular diseases such as atherosclerosis, hypertension and restenosis, and their complications, including myocardial infarction or stroke. Accumulating evidence suggests that bone marrow-derived endothelial progenitor cells (EPCs) promote endothelial repair and contribute to ischemia-induced neovascularization. Coronary artery disease and its risk factors, such as diabetes, hypercholesterolemia, hypertension and smoking, are associated with a reduced number and impaired functional activity of circulating EPCs. Moreover, first data suggest that reduced EPC levels are associated with endothelial dysfunction and an increased risk of cardiovascular events, compatible with the concept that impaired EPC-mediated vascular repair promotes progression of vascular disease.
In the present review article we summarize recent data on the effects of pharmacological agents on mobilization and functional activity of EPCs. In particular, several experimental and clinical studies have suggested that statins, angiotensin-converting enzyme inhibitors, angiotensin II type 1 receptor blocker, PPAR-gamma agonists and erythropoietin increase the number and functional activity of EPCs. The underlying mechanisms remain largely to be defined; however, they likely include activation of the PI3-kinase/Akt pathway and endothelial nitric oxide synthase, as well as inhibition of NAD(P)H oxidase activity of progenitor cells.
7 downloads since deposited on 20 Oct 2008
0 downloads since 12 months
|Item Type:||Journal Article, refereed, further contribution|
|Communities & Collections:||04 Faculty of Medicine > Center for Integrative Human Physiology
04 Faculty of Medicine > University Hospital Zurich > Clinic for Cardiology
|DDC:||570 Life sciences; biology
610 Medicine & health
|Deposited On:||20 Oct 2008 13:03|
|Last Modified:||24 Jan 2013 19:40|
|Publisher:||Expert Reviews (formerly Future Drugs)|
|Additional Information:||Full text at http://www.expert-reviews.com/doi/abs/10.1586/14779072.6.8.1071?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dncbi.nlm.nih.gov|
Users (please log in): suggest update or correction for this item
Repository Staff Only: item control page