Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-4508
Kranich, J; Krautler, N J; Heinen, E; Polymenidou, M; Bridel, C; Schildknecht, A; Huber, C; Kosco-Vilbois, M H; Zinkernagel, R; Miele, G; Aguzzi, A (2008). Follicular dendritic cells control engulfment of apoptotic bodies by secreting Mfge8. Journal of Experimental Medicine, 205(6):1293-1302.
The secreted phosphatidylserine-binding protein milk fat globule epidermal growth factor 8 (Mfge8) mediates engulfment of apoptotic germinal center B cells by tingible-body macrophages (TBMphis). Impairment of this process can contribute to autoimmunity. We show that Mfge8 is identical to the mouse follicular dendritic cell (FDC) marker FDC-M1. In bone-marrow chimeras between wild-type and Mfge8(-/-) mice, all splenic Mfge8 was derived from FDCs rather than TBMphis. However, Mfge8(-/-) TBMphis acquired and displayed Mfge8 only when embedded in Mfge8(+/+) stroma, or when situated in lymph nodes draining exogenous recombinant Mfge8. These findings indicate a licensing role for FDCs in TBMphi-mediated removal of excess B cells. Lymphotoxin-deficient mice lacked FDCs and splenic Mfge8, and suffer from autoimmunity similar to Mfge8(-/-) mice. Hence, FDCs facilitate TBMphi-mediated corpse removal, and their malfunction may be involved in autoimmunity.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Institute of Neuropathology|
|DDC:||570 Life sciences; biology|
610 Medicine & health
|Date:||09 June 2008|
|Deposited On:||18 Dec 2008 08:28|
|Last Modified:||27 Nov 2013 19:39|
|Publisher:||Rockefeller University Press|
|Citations:||Web of Science®. Times cited: 67|
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