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Primate early life stress leads to long-term mild hippocampal decreases in corticosteroid receptor expression


Arabadzisz, D; Diaz-Heijtz, R; Knuesel, I; Weber, E; Pilloud, S; Dettling, A C; Feldon, J; Law, A J; Harrison, P J; Pryce, C R (2010). Primate early life stress leads to long-term mild hippocampal decreases in corticosteroid receptor expression. Biological Psychiatry, 67(11):1106-1109.

Abstract

In adolescent marmoset monkey brains, reduced hippocampal expression of MR and GR are consistent chronic-indicators of ELS. It is unlikely that these chronic, mild, specific reductions were acute-mediators of the observed long-term emotional effects of ELS. However, they do suggest involvement of hippocampal MR/GR in the neurodevelopmental effects of ELS.

In adolescent marmoset monkey brains, reduced hippocampal expression of MR and GR are consistent chronic-indicators of ELS. It is unlikely that these chronic, mild, specific reductions were acute-mediators of the observed long-term emotional effects of ELS. However, they do suggest involvement of hippocampal MR/GR in the neurodevelopmental effects of ELS.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Psychiatric University Hospital Zurich > Clinic for Psychiatry, Psychotherapy, and Psychosomatics
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2010
Deposited On:10 Feb 2011 13:57
Last Modified:05 Apr 2016 14:45
Publisher:Elsevier
ISSN:0006-3223
Publisher DOI:https://doi.org/10.1016/j.biopsych.2009.12.016
PubMed ID:20132928
Permanent URL: https://doi.org/10.5167/uzh-45235

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