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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-45264

Gupta, S; Soellinger, M; Grzybowski, D M; Boesiger, P; Biddiscombe, J; Poulikakos, D; Kurtcuoglu, V (2010). Cerebrospinal fluid dynamics in the human cranial subarachnoid space: an overlooked mediator of cerebral disease. I. Computational model. Journal of the Royal Society Interface, 7(49):1195-1204.

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Abnormal cerebrospinal fluid (CSF) flow is suspected to be a contributor to the pathogenesis of neurodegenerative diseases such as Alzheimer's through the accumulation of toxic metabolites, and to the malfunction of intracranial pressure regulation, possibly through disruption of neuroendocrine communication. For the understanding of transport processes involved in either, knowledge of in vivo CSF dynamics is important. We present a three-dimensional, transient, subject-specific computational analysis of CSF flow in the human cranial subarachnoid space (SAS) based on in vivo magnetic resonance imaging. We observed large variations in the spatial distribution of flow velocities with a temporal peak of 5 cm s(-1) in the anterior SAS and less than 4 mm s(-1) in the superior part. This could reflect dissimilar flushing requirements of brain areas that may show differences in susceptibility to pathological CSF flow. Our methods can be used to compare the transport of metabolites and neuroendocrine substances in healthy and diseased brains.


24 citations in Web of Science®
26 citations in Scopus®
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1 download since deposited on 22 Feb 2011
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Biomedical Engineering
Dewey Decimal Classification:170 Ethics
610 Medicine & health
Deposited On:22 Feb 2011 09:18
Last Modified:05 Apr 2016 14:45
Publisher:Royal Society Publishing
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:10.1098/rsif.2010.0033
PubMed ID:20236960

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