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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-45295

Stoeck, C T; Hu, P; Peters, D C; Kissinger, K V; Goddu, B; Goepfert, L; Ngo, L; Manning, W J; Kozerke, S; Nezafat, R (2010). Optimization of on-resonant magnetization transfer contrast in coronary vein MRI. Magnetic Resonance in Medicine, 64(6):1849-54.

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Magnetization transfer contrast has been used commonly for endogenous tissue contrast improvements in angiography, brain, body, and cardiac imaging. Both off-resonant and on-resonant RF pulses can be used to generate magnetization transfer based contrast. In this study, on-resonant magnetization transfer preparation using binomial pulses were optimized and compared with off-resonant magnetization transfer for imaging of coronary veins. Three parameters were studied with simulations and in vivo measurements: flip angle, pulse repetitions, and binomial pulse order. Subsequently, first or second order binomial on-resonant magnetization transfer pulses with eight repetitions of 720° and 240° flip angle were used for coronary vein MRI. Flip angles of 720° yielded contrast enhancement of 115% (P < 0.0006) for first order on-resonant and 95% (P < 0.0006) for off-resonant magnetization transfer. There was no statistically significance difference between off-resonant and on-resonant first order binomial Magnetization transfer at 720°. However, for off-resonance pulses, much more preparation time is needed when compared with the binomials but with considerably reduced specific absorption rate.


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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Biomedical Engineering
Dewey Decimal Classification:170 Ethics
610 Medicine & health
Deposited On:14 Feb 2011 09:46
Last Modified:05 Apr 2016 14:45
Publisher DOI:10.1002/mrm.22581
PubMed ID:20938974

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