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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-45310

Utting, J F; Kozerke, S; Schnitker, R; Niendorf, T (2010). Comparison of k-t SENSE/k-t BLAST with conventional SENSE applied to BOLD fMRI. Journal of Magnetic Resonance Imaging, 32(1):235-241.

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PURPOSE: To compare k-t BLAST (broad-use linear-acquisition speedup technique)/k-t SENSE (sensitivity encoding) with conventional SENSE applied to a simple fMRI paradigm.

MATERIALS AND METHODS: Blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) was performed at 3 T using a displaced ultra-fast low-angle refocused echo (UFLARE) pulse sequence with a visual stimulus in a block paradigm. Conventional SENSE and k-t BLAST/k-t SENSE data were acquired. Also, k-t BLAST/k-t SENSE was simulated at different undersampling factors from fully sampled data after removal of lines of k-space data. Analysis was performed using SPM5.

RESULTS: Sensitivity to the BOLD response in k-t BLAST/k-t SENSE was comparable with that of SENSE in images acquired at an undersampling factor of 2.3. Simulated k-t BLAST/k-t SENSE yielded reliable detection of activation-induced BOLD contrast at undersampling factors of 5 or less. Sensitivity increased significantly when training data were included in k-space before Fourier transformation (known as "plug-in").

CONCLUSION: k-t BLAST/k-t SENSE performs at least as well as conventional SENSE for BOLD fMRI at a modest undersampling factor. Results suggest that sufficient sensitivity to BOLD contrast may be achievable at higher undersampling factors with k-t BLAST/k-t SENSE than with conventional parallel imaging approaches, offering particular advantages at the highest magnetic field strengths.


5 citations in Web of Science®
6 citations in Scopus®
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Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Biomedical Engineering
Dewey Decimal Classification:170 Ethics
610 Medicine & health
Deposited On:14 Feb 2011 07:59
Last Modified:05 Apr 2016 14:45
Publisher DOI:10.1002/jmri.22212
PubMed ID:20578030

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