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TB drug resistance in a low endemic area 2004 to 2006: semi-quantitative drug susceptibility testing and genotyping


Springer, B; Calligaris-Maibach, R C; Ritter, C; Böttger, E C (2008). TB drug resistance in a low endemic area 2004 to 2006: semi-quantitative drug susceptibility testing and genotyping. Journal of Clinical Microbiology, 46(12):4064-4067.

Abstract

We determined quantitative levels and genetic mechanisms of resistance in drug resistant clinical isolates of Mycobacterium tuberculosis sampled over a period of three years (n = 45, 17 of which MDR). Our results lead us to hypothesize that some strains categorized by standard laboratory procedures of in vitro drug susceptibility testing as resistant to isoniazid, ethambutol or streptomycin may still respond to a treatment regimen including these agents.

We determined quantitative levels and genetic mechanisms of resistance in drug resistant clinical isolates of Mycobacterium tuberculosis sampled over a period of three years (n = 45, 17 of which MDR). Our results lead us to hypothesize that some strains categorized by standard laboratory procedures of in vitro drug susceptibility testing as resistant to isoniazid, ethambutol or streptomycin may still respond to a treatment regimen including these agents.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Medical Microbiology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:December 2008
Deposited On:06 Nov 2008 13:06
Last Modified:05 Apr 2016 12:30
Publisher:American Society for Microbiology
ISSN:0095-1137
Additional Information:Copyright: American Society for Microbiology
Publisher DOI:10.1128/JCM.01114-08
PubMed ID:18923010
Permanent URL: http://doi.org/10.5167/uzh-4537

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