Quick Search:

uzh logo
Browse by:

Zurich Open Repository and Archive

Maintenance: Tuesday, 5.7.2016, 07:00-08:00

Maintenance work on ZORA and JDB on Tuesday, 5th July, 07h00-08h00. During this time there will be a brief unavailability for about 1 hour. Please be patient.

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-45496

Epelman, M; Daneman, A; Kellenberger, C J; Aziz, A; Konen, O; Moineddin, R; Whyte, H; Blaser, S (2010). Neonatal encephalopathy: a prospective comparison of head US and MRI. Pediatric Radiology, 40(10):1640-1650.

[img] PDF - Registered users only
View at publisher


BACKGROUND: Head US, the cornerstone neuroimaging modality in neonates, is believed to be less sensitive than MRI for detecting hypoxic ischemic injury (HII). Most reports comparing these modalities are retrospective and have a long interval between the exams.

OBJECTIVE: To prospectively characterize the range of abnormalities found in US examinations performed within 2 h of brain MRI in encephalopathic neonates.

MATERIALS AND METHODS: A total of 76 consecutive exams met our inclusion criteria. Diagnostic performance of the US images was prospectively compared with MRI.

RESULTS: MRI was considered positive for HII in 53 neonates. Of the remaining 23, MRI was negative for HII in 9, showed white matter abnormalities unrelated to HII in 8, and was inconclusive in 6. Of the 70 neonates with conclusive examinations, the US exam was regarded as positive in 67. Diagnostic accuracy of US was 95.7%.

CONCLUSION: Our study demonstrates that US should still be regarded as a screening test in neonates. US is more sensitive for the detection of injury than previously reported, and more attention should be paid to proper US technique. MRI shows disease more extensively and should be accomplished as early as possible.


21 citations in Web of Science®
26 citations in Scopus®
Google Scholar™



1 download since deposited on 11 Feb 2011
0 downloads since 12 months

Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Children's Hospital Zurich > Medical Clinic
Dewey Decimal Classification:610 Medicine & health
Deposited On:11 Feb 2011 15:34
Last Modified:05 Apr 2016 14:46
Publisher DOI:10.1007/s00247-010-1634-6
PubMed ID:20411255

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page