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Origins of regulated cell-to-cell variability


Snijder, B; Pelkmans, L (2011). Origins of regulated cell-to-cell variability. Nature Reviews. Molecular Cell Biology, 12(2):119-125.

Abstract

Single-cell measurements and lineage-tracing experiments are revealing that phenotypic cell-to-cell variability is often the result of deterministic processes, despite the existence of intrinsic noise in molecular networks. In most cases, this determinism represents largely uncharacterized molecular regulatory mechanisms, which places the study of cell-to-cell variability in the realm of molecular cell biology. Further research in the field will be important to advance quantitative cell biology because it will provide new insights into the mechanisms by which cells coordinate their intracellular activities in the spatiotemporal context of the multicellular environment.

Abstract

Single-cell measurements and lineage-tracing experiments are revealing that phenotypic cell-to-cell variability is often the result of deterministic processes, despite the existence of intrinsic noise in molecular networks. In most cases, this determinism represents largely uncharacterized molecular regulatory mechanisms, which places the study of cell-to-cell variability in the realm of molecular cell biology. Further research in the field will be important to advance quantitative cell biology because it will provide new insights into the mechanisms by which cells coordinate their intracellular activities in the spatiotemporal context of the multicellular environment.

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122 citations in Web of Science®
138 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Date:February 2011
Deposited On:22 Feb 2011 14:54
Last Modified:05 Apr 2016 14:46
Publisher:Nature Publishing Group
ISSN:1471-0072
Publisher DOI:https://doi.org/10.1038/nrm3044
PubMed ID:21224886

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