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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-45879

Haller , C; Buerzle, W; Brubaker, C E; Messersmith, P B; Mazza, E; Ochsenbein-Kölble, N; Zimmermann, R; Ehrbar, M (2011). Mussel-mimetic tissue adhesive for fetal membrane repair: a standardized ex vivo evaluation using elastomeric membranes. Prenatal Diagnosis, 31(7):654-660.

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Objective Iatrogenic preterm premature rupture of membranes (iPPROM), the main complication of invasive interventions in the prenatal period, seriously limits the benefit of diagnostic or surgical prenatal procedures. This study aimed to evaluate preventive plugging of punctured fetal membranes in an ex vivo situation using a new mussel-mimetic tissue adhesive (mussel glue) to inhibit leakage. Methods A novel biomechanical test device that tests the closure of injured membranes under nearphysiological conditions was used. Mussel glue, a poly(ethylene glycol)-based hydrogel, was used to seal membrane defects of up to 3mm in mechanically well-defined elastomeric membranes with three different degrees of stiffness. Results Elastomeric test membranes were successfully employed for testing mussel glue under welldefined conditions. Mussel glue plugs were distended by up to 94%, which translated to an improved sealing efficiency on elastomeric membranes with high stiffness. For the stiffest membrane tested, a critical burst pressure of 48mbar (36mmHg) was accomplished in this ex vivo setting. Conclusions Mussel glue appears to efficiently seal membrane defects under well standardized ex vivo conditions. As repaired membranes resist pressures measured in amniotic cavities, mussel glue might represent a novel sealing method for iatrogenic membrane defects.


16 citations in Web of Science®
18 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Obstetrics
Dewey Decimal Classification:610 Medicine & health
Deposited On:15 Feb 2011 14:35
Last Modified:27 Nov 2013 23:36
Additional Information:The attached file is a preprint (accepted version) of an article published in Prenatal Diagnosis.
Publisher DOI:10.1002/pd.2712

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