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PSP/reg inhibits cultured pancreatic stellate cell and regulates MMP/ TIMP ratio


Li, L; Bimmler, D; Graf, R; Zhou, S; Sun, Z; Chen, J; Siech, M; Bachem, M G (2011). PSP/reg inhibits cultured pancreatic stellate cell and regulates MMP/ TIMP ratio. European Journal of Clinical Investigation, 41(2):151-158.

Abstract

Our work describes a novel aspect that in vitro PSP/reg reduces PSC activity (proliferation and migration) and stimulates fibrolysis by increasing MMP/TIMP ratio. The findings suggest that PSP/reg might have a protective function in the repair phase of acute and chronic pancreatitis by promoting resolution of fibrosis. We highlight PSP/reg as an antifibrogenic protein in pancreatic injury.

Our work describes a novel aspect that in vitro PSP/reg reduces PSC activity (proliferation and migration) and stimulates fibrolysis by increasing MMP/TIMP ratio. The findings suggest that PSP/reg might have a protective function in the repair phase of acute and chronic pancreatitis by promoting resolution of fibrosis. We highlight PSP/reg as an antifibrogenic protein in pancreatic injury.

Citations

13 citations in Web of Science®
16 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Division of Surgical Research
04 Faculty of Medicine > University Hospital Zurich > Clinic for Visceral and Transplantation Surgery
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2011
Deposited On:14 Apr 2011 07:42
Last Modified:05 Apr 2016 14:47
Publisher:Wiley-Blackwell
ISSN:0014-2972
Publisher DOI:https://doi.org/10.1111/j.1365-2362.2010.02390.x
PubMed ID:20860757

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