Li, L; Bimmler, D; Graf, R; Zhou, S; Sun, Z; Chen, J; Siech, M; Bachem, M G (2011). PSP/reg inhibits cultured pancreatic stellate cell and regulates MMP/ TIMP ratio. European Journal of Clinical Investigation, 41(2):151-158.
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Our work describes a novel aspect that in vitro PSP/reg reduces PSC activity (proliferation and migration) and stimulates fibrolysis by increasing MMP/TIMP ratio. The findings suggest that PSP/reg might have a protective function in the repair phase of acute and chronic pancreatitis by promoting resolution of fibrosis. We highlight PSP/reg as an antifibrogenic protein in pancreatic injury.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Division of Surgical Research|
04 Faculty of Medicine > University Hospital Zurich > Clinic for Visceral and Transplantation Surgery
|DDC:||610 Medicine & health|
|Deposited On:||14 Apr 2011 09:42|
|Last Modified:||27 Nov 2013 21:42|
|Citations:||Web of Science®. Times Cited: 5|
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