Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-4597
Eckstein, Cindy; Guscetti, Franco; Roos, Malgorzata; de las Mulas, M J; Kaser-Hotz, Barbara; Rohrer Bley, Carla (2009). A retrospective analysis of radiation therapy for the treament of feline vaccine-associated sarcoma. Veterinary and Comparative Oncology, 7(1):54-68.
We retrospectively evaluated predictive prognostic factors in 73 cats with vaccineassociated sarcoma given postsurgical curative (n=46, most with clean margins) or coarse fractionated radiotherapy (n=27, most with either macroscopic disease or dirty margins). The former animals displayed a median survival of 43 months and a median progression free interval (PFI) of 37 months, the latter reached a median survival of 24 months and a median PFI of 10 months. In cats undergoing coarse fractionated therapy, factors predictive of a better outcome included lack of visible mass (n=10) as opposed to macroscopic disease (n=17, survival: 30 vs. 7 months, P=0.025; PFI: 20 vs. 4 months, P=0.01), adjuvant chemotherapy for gross disease (n=5/17, survival: 29 vs. 5 months, P=0.04) and a smaller number of surgeries preceding radiation therapy (Coeff=0.41,^P=0.03). The Ki67-index was not predictive for survival. We concluded that postsurgical curative and coarse fractionated radiotherapy are both effective legitimate options for managing vaccine-associated sarcomas.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > Institute of Social and Preventive Medicine|
05 Vetsuisse Faculty > Veterinary Clinic > Department of Small Animals > Division of Radiation Oncology
05 Vetsuisse Faculty > Institute of Veterinary Pathology
|DDC:||570 Life sciences; biology|
610 Medicine & health
|Deposited On:||04 Feb 2009 17:53|
|Last Modified:||17 Jan 2013 21:33|
|Additional Information:||Submitted as Doctoral thesis of Cindy Eckstein|
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