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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-4597

Eckstein, Cindy; Guscetti, Franco; Roos, Malgorzata; de las Mulas, M J; Kaser-Hotz, Barbara; Rohrer Bley, Carla (2009). A retrospective analysis of radiation therapy for the treament of feline vaccine-associated sarcoma. Veterinary and Comparative Oncology, 7(1):54-68.

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Abstract

We retrospectively evaluated predictive prognostic factors in 73 cats with vaccineassociated sarcoma given postsurgical curative (n=46, most with clean margins) or coarse fractionated radiotherapy (n=27, most with either macroscopic disease or dirty margins). The former animals displayed a median survival of 43 months and a median progression free interval (PFI) of 37 months, the latter reached a median survival of 24 months and a median PFI of 10 months. In cats undergoing coarse fractionated therapy, factors predictive of a better outcome included lack of visible mass (n=10) as opposed to macroscopic disease (n=17, survival: 30 vs. 7 months, P=0.025; PFI: 20 vs. 4 months, P=0.01), adjuvant chemotherapy for gross disease (n=5/17, survival: 29 vs. 5 months, P=0.04) and a smaller number of surgeries preceding radiation therapy (Coeff=0.41,^P=0.03). The Ki67-index was not predictive for survival. We concluded that postsurgical curative and coarse fractionated radiotherapy are both effective legitimate options for managing vaccine-associated sarcomas.

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10 citations in Web of Science®
20 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Epidemology, Biostatistics and Prevention Institute (EBPI)
05 Vetsuisse Faculty > Institute of Veterinary Pathology
05 Vetsuisse Faculty > Veterinary Clinic > Department of Small Animals
DDC:570 Life sciences; biology
610 Medicine & health
Language:English
Date:March 2009
Deposited On:04 Feb 2009 16:53
Last Modified:30 Oct 2014 15:35
Publisher:Wiley-Blackwell
ISSN:1476-5810
Additional Information:Submitted as Doctoral thesis of Cindy Eckstein
Publisher DOI:10.1111/j.1476-5829.2008.00173.x
Related URLs:https://www.zora.uzh.ch/12390/
PubMed ID:19222831

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