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Disease progression and search for monogenic diabetes among children with new onset type 1 diabetes negative for ICA, GAD- and IA-2 Antibodies


Pörksen, S; Laborie, L B; et al; Schönle, E J (2010). Disease progression and search for monogenic diabetes among children with new onset type 1 diabetes negative for ICA, GAD- and IA-2 Antibodies. BMC endocrine disorders, (10):16.

Abstract

GAD, IA-2A, and ICA negative children with new onset type 1 diabetes have slower disease progression as assessed by residual beta-cell function and improved glycemic control 12 months after diagnosis. One out of 24 had a mutation in ABCC8, suggesting that screening of ABCC8 should be considered in patients with AAB negative type 1 diabetes.

GAD, IA-2A, and ICA negative children with new onset type 1 diabetes have slower disease progression as assessed by residual beta-cell function and improved glycemic control 12 months after diagnosis. One out of 24 had a mutation in ABCC8, suggesting that screening of ABCC8 should be considered in patients with AAB negative type 1 diabetes.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Children's Hospital Zurich > Medical Clinic
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2010
Deposited On:21 Feb 2011 16:17
Last Modified:05 Apr 2016 14:47
Publisher:UNSPECIFIED
ISSN:1472-6823
Publisher DOI:https://doi.org/10.1186/1472-6823-10-16
Related URLs:http://www.biomedcentral.com/1472-6823/10/16 (Publisher)
PubMed ID:20863361
Permanent URL: https://doi.org/10.5167/uzh-46032

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