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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-46210

Flierl, M A; Rittirsch, D; Huber-Lang, M S; Stahel, P F (2010). Pathophysiology of septic encephalopathy-an unsolved puzzle. Critical Care, 14(3):165.

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Abstract

The exact cellular and molecular mechanisms of sepsis-induced encephalopathy remain elusive. The breakdown of the blood-brain barrier (BBB) is considered a focal point in the development of sepsis-induced brain damage. Contributing factors for the compromise of the BBB include cytokines and chemokines, activation of the complement cascade, phagocyte-derived toxic mediators, and bacterial products. To date, we are far from fully understanding the neuropathology that develops as a secondary remote organ injury as a consequence of sepsis. However, recent studies suggest that bacterial proteins may readily cross the functional BBB and trigger an inflammatory response in the subarachnoid space, in absence of a bacterial invasion. A better understanding of the pathophysiological events leading to septic encephalopathy appears crucial to advance the clinical care for this vulnerable patient population.

Contributors:Department of Orthopaedic Surgery, University of Colorado School of Medicine, Denver Health Medical Center, 777 Bannock Street, Denver, CO 80204, USA. michael.flierl@dhha.org
Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Trauma Surgery
DDC:610 Medicine & health
Language:English
Date:2010
Deposited On:21 Feb 2011 09:42
Last Modified:31 Jan 2014 05:43
Publisher:BioMed Central
ISSN:1364-8535
Publisher DOI:10.1186/cc9035
PubMed ID:20565858
Citations:Web of Science®. Times Cited: 10
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Scopus®. Citation Count: 14

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