Liu, Y; Oliveira, B L; Correia, J D G; Santos, I C; Santos, I; Spingler, B; Alberto, R (2010). Syntheses of bifunctional 2,3-diamino propionic acid-based chelators as small and strong tripod ligands for the labelling of biomolecules with (99m)Tc. Organic & Biomolecular Chemistry, 8(12):2829-2839.
Full text not available from this repository.
View at publisher
The labelling of targeting biomolecules requires small and hydrophilic complexes in order to not affect the binding properties of the vectors. 2,3-Diamino propionic acid (dap) is a small and strong, albeit scarcely used, tripod ligand for the fac-Tc-99m(CO)(3)](+) moiety. We have introduced at the alpha-carbon atom in the basic dap structure various second functionalities such as carboxylato, amino and alpha-amino acid groups via various spacers in order to yield bifunctional chelators. These dap derivatives can be coupled to targeting molecules for application in molecular imaging. Full characterizations of the bifunctional chelators, X-ray structures of intermediates and of one rhenium complex, as well as labelling studies with Tc-99m, are presented.
0 downloads since deposited on 23 Feb 2011
0 downloads since 12 months
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||07 Faculty of Science > Department of Chemistry|
|Deposited On:||23 Feb 2011 17:24|
|Last Modified:||27 Nov 2013 17:18|
|Publisher:||Royal Society of Chemistry|
|Other Identification Number:||ISI:000278964600020|
Users (please log in): suggest update or correction for this item
Repository Staff Only: item control page