Grotzer, M A; Shalaby, T; Arcaro, A (2011). Central nervous system atyypical teratoid/rhabdoid tumors: role of insulin-like factor I receptor. In: Hayat, M A. Methods of Cancer Diagnosis, Therapy, and Prognosis: Brain Cancer. Heidelberg: Springer , 353-364.
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Central nervous system (CNS) atypical teratoid/rhabdoid tumors (AT/RT) are among the pediatric malignant tumors with the worst prognosis. Insulin-like growth factor I receptor (IGF-IR) protects cancer cells from apoptosis induced by a variety of anticancer drugs and radiation. IGF-IR is expressed in primary CNS AT/RT as detected by immunohistochemistry. Moreover, there is evidence for the potential presence of an autocrine/paracrine IGF-I/II/IGF-IR loop in CNS AT/RT. IGF-IR antisense oligonucleotide treatment of human CNS AT/RT cells results in significant down-regulation of IGF-IR mRNA and protein expression, induction of apoptosis, and chemosensitization to doxorubicin and cisplatin. These studies provide evidence for the influence of IGF-IR on cellular responses to chemotherapy and raise the possibility that curability of selected CNS AT/RT may be improved by pharmaceutical strategies directed toward the IGF-IR
|Item Type:||Book Section, not refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > University Children's Hospital Zurich > Medical Clinic|
|Dewey Decimal Classification:||610 Medicine & health|
|Deposited On:||24 Feb 2012 10:21|
|Last Modified:||27 Nov 2013 23:57|
|Series Name:||Methods of Cancer Diagnosis, Therapy and Prognosis|
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