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Central nervous system atyypical teratoid/rhabdoid tumors: role of insulin-like factor I receptor


Grotzer, M A; Shalaby, T; Arcaro, A (2011). Central nervous system atyypical teratoid/rhabdoid tumors: role of insulin-like factor I receptor. In: Hayat, M A. Methods of Cancer Diagnosis, Therapy, and Prognosis: Brain Cancer. Heidelberg: Springer , 353-364.

Abstract

Central nervous system (CNS) atypical teratoid/rhabdoid tumors (AT/RT) are among the pediatric malignant tumors with the worst prognosis. Insulin-like growth factor I receptor (IGF-IR) protects cancer cells from apoptosis induced by a variety of anticancer drugs and radiation. IGF-IR is expressed in primary CNS AT/RT as detected by immunohistochemistry. Moreover, there is evidence for the potential presence of an autocrine/paracrine IGF-I/II/IGF-IR loop in CNS AT/RT. IGF-IR antisense oligonucleotide treatment of human CNS AT/RT cells results in significant down-regulation of IGF-IR mRNA and protein expression, induction of apoptosis, and chemosensitization to doxorubicin and cisplatin. These studies provide evidence for the influence of IGF-IR on cellular responses to chemotherapy and raise the possibility that curability of selected CNS AT/RT may be improved by pharmaceutical strategies directed toward the IGF-IR

Central nervous system (CNS) atypical teratoid/rhabdoid tumors (AT/RT) are among the pediatric malignant tumors with the worst prognosis. Insulin-like growth factor I receptor (IGF-IR) protects cancer cells from apoptosis induced by a variety of anticancer drugs and radiation. IGF-IR is expressed in primary CNS AT/RT as detected by immunohistochemistry. Moreover, there is evidence for the potential presence of an autocrine/paracrine IGF-I/II/IGF-IR loop in CNS AT/RT. IGF-IR antisense oligonucleotide treatment of human CNS AT/RT cells results in significant down-regulation of IGF-IR mRNA and protein expression, induction of apoptosis, and chemosensitization to doxorubicin and cisplatin. These studies provide evidence for the influence of IGF-IR on cellular responses to chemotherapy and raise the possibility that curability of selected CNS AT/RT may be improved by pharmaceutical strategies directed toward the IGF-IR

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Additional indexing

Item Type:Book Section, not refereed, original work
Communities & Collections:04 Faculty of Medicine > University Children's Hospital Zurich > Medical Clinic
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2011
Deposited On:24 Feb 2012 10:21
Last Modified:05 Apr 2016 14:48
Publisher:Springer
Series Name:Methods of Cancer Diagnosis, Therapy and Prognosis
Number:8
ISBN:978-90-481-8665-5
Publisher DOI:https://doi.org/10.1007/978-90-481-8665-5_27
Related URLs:http://dx.doi.org/10.1007/978-90-481-8665-5

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