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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-46352

Knols, R H; de Bruin, E D; Uebelhart, D; Aufdemkampe, G; Schanz, U; Stenner-Liewen, F; Hitz, F; Taverna, C; Aaronson, N K (2011). Effects of an outpatient physical exercise program on hematopoietic stem-cell transplantation recipients: a randomized clinical trial. Bone Marrow Transplantation, 46(9):1245-1255.

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Patients who undergo hematopoietic stem cell transplantation (HSCT) often experience physical and psychological problems, even long after treatment has been completed. This study was performed to evaluate the effects of a 12-week outpatient physical exercise program, incorporating aerobic and strength exercises, as compared to a usual care control condition on patients’ physical performance and psychosocial well-being.
Methods: Patients who had completed HSCT up to 6 months earlier were randomly assigned to a supervised physical exercise program (n = 64) or a usual care control group
(n = 67). Primary outcomes were quantified physical performance and self-reported physical functioning. Secondary outcomes were body composition measurement, quantified walking activity and patient-reported outcomes (physical activity, fatigue and health-related quality of life). Assessments were at baseline, immediately after program completion and at 3-month follow-up.
Results: Significant intervention effects were observed at both post-treatment and follow-up on physical performance measures. No other outcomes yielded statistically significant group differences.
Conclusion: Physical exercise should be considered in the management of HSCT recipients to improve physical performance after discharge from hospital. Further research is needed to determine how the program can be enhanced so that improved physical performance also translates into improved physical and psychosocial functioning in daily life.


26 citations in Web of Science®
27 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Rheumatology Clinic and Institute of Physical Medicine
Dewey Decimal Classification:610 Medicine & health
Deposited On:22 Feb 2011 10:21
Last Modified:05 Apr 2016 14:48
Publisher:Nature Publishing Group
Publisher DOI:10.1038/bmt.2010.288
PubMed ID:21132025

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