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The photophysics of europium and terbium polyoxometalates and their interaction with serum albumin: a time-resolved luminescence study


Hungerford, G; Hussain, F; Patzke, G R; Green, M (2010). The photophysics of europium and terbium polyoxometalates and their interaction with serum albumin: a time-resolved luminescence study. Physical Chemistry Chemical Physics (PCCP), 12(26):7266-7275.

Abstract

Polyoxometalates (POMs) are emerging as useful materials for a variety of applications. Many show potential for use in the biological and medical. fields. Those incorporating lanthanides, with their narrow emission bands, large Stokes' shift and tuneable emission are of particular interest for the labelling and imaging of biological molecules. Their longer emission timescale (mu s to ms) also allows autofluorescence from the biological samples to be removed by time gating the emission decay. This means that the characterisation of their photophysical properties is required to enable their application. In this work we present a time-resolved emission study of two types of POM structure, a simple europium containing decatungstate and a more complex high nuclear polyoxotungstate, containing either europium or terbium. A concentration study, made monitoring the lanthanide emission helped elucidate POM-POM interactions. The use of global analysis hints at the presence of defined POM aggregates. Interaction with serum albumin was ascertained, both by monitoring the lanthanide emission of the POM and the tryptophan emission from the serum albumin. This showed that the more complex structure had a significantly higher affinity for the protein than the simple structure.

Polyoxometalates (POMs) are emerging as useful materials for a variety of applications. Many show potential for use in the biological and medical. fields. Those incorporating lanthanides, with their narrow emission bands, large Stokes' shift and tuneable emission are of particular interest for the labelling and imaging of biological molecules. Their longer emission timescale (mu s to ms) also allows autofluorescence from the biological samples to be removed by time gating the emission decay. This means that the characterisation of their photophysical properties is required to enable their application. In this work we present a time-resolved emission study of two types of POM structure, a simple europium containing decatungstate and a more complex high nuclear polyoxotungstate, containing either europium or terbium. A concentration study, made monitoring the lanthanide emission helped elucidate POM-POM interactions. The use of global analysis hints at the presence of defined POM aggregates. Interaction with serum albumin was ascertained, both by monitoring the lanthanide emission of the POM and the tryptophan emission from the serum albumin. This showed that the more complex structure had a significantly higher affinity for the protein than the simple structure.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Language:English
Date:2010
Deposited On:24 Feb 2011 18:52
Last Modified:05 Apr 2016 14:49
Publisher:Royal Society of Chemistry
ISSN:1463-9076
Publisher DOI:https://doi.org/10.1039/b925547h
PubMed ID:20490399
Other Identification Number:ISI:000279098300043

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