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Conditional deletion of BMP7 from the limb skeleton does not affect bone formation or fracture repair


Tsuji, K; Cox, K; Gamer, L; Graf, D (2010). Conditional deletion of BMP7 from the limb skeleton does not affect bone formation or fracture repair. Journal of Orthopaedic Research, 28(3):384-389.

Abstract

While the osteoinductive activity of recombinant bone morphogenetic protein 7 (BMP7) is well established, evaluation of the role of endogenous BMP7 in bone formation and fracture healing has been hampered by perinatal lethality in BMP7 knockout mice. Here we employ conditional deletion of BMP7 from the embryonic limb prior to the onset of skeletogenesis to create limb bones lacking BMP7. We find that the absence of locally produced BMP7 has no effect on postnatal limb growth, articular cartilage formation, maintenance of bone mass, or fracture healing. Our data suggest that other BMPs present in adult bone are sufficient to compensate for the absence of BMP7.

While the osteoinductive activity of recombinant bone morphogenetic protein 7 (BMP7) is well established, evaluation of the role of endogenous BMP7 in bone formation and fracture healing has been hampered by perinatal lethality in BMP7 knockout mice. Here we employ conditional deletion of BMP7 from the embryonic limb prior to the onset of skeletogenesis to create limb bones lacking BMP7. We find that the absence of locally produced BMP7 has no effect on postnatal limb growth, articular cartilage formation, maintenance of bone mass, or fracture healing. Our data suggest that other BMPs present in adult bone are sufficient to compensate for the absence of BMP7.

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21 citations in Web of Science®
24 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Center for Dental Medicine > Institute of Oral Biology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:28 March 2010
Deposited On:25 Feb 2011 07:57
Last Modified:05 Apr 2016 14:50
Publisher:Wiley-Blackwell
ISSN:0736-0266
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1002/jor.20996
PubMed ID:19780203
Permanent URL: https://doi.org/10.5167/uzh-46790

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