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Lack of association between 71 variations located in candidate genes and response to acute haloperidol treatment


Giegling, I; Drago, A; Schäfer, M; Hartmann, A M; Sander, T; Toliat, M R; Möller, H J; De Ronchi, D; Stassen, H H; Rujescu, D; Serretti, A (2011). Lack of association between 71 variations located in candidate genes and response to acute haloperidol treatment. Psychopharmacology, 214(3):719-728.

Abstract

RATIONALE: The antipsychotic pharmacological treatment effectiveness and side effects are at least partially driven by the genetic personal background. OBJECTIVES: In the present study, 71 genetic variations located in 21 candidate genes were investigated as modulators of the haloperidol efficacy and side effects in a sample of 101 acutely ill psychotic patients. METHODS: Patients were assessed at days 0, 7, 14, 21, and 28 (Positive and Negative Syndrome Scale (PANSS) test) and days 1, 3, 7, 14, 21, and 28 (UKU, BAS, and ESRS tests). Haloperidol plasma levels were measured at the same timepoints. RESULTS: None of the 71 variations were associated with response to treatment or with incidence of side effects passed a multiple testing threshold. A marginal association was detected between two haplotypes within the signal transducer and activator of transcription 4 gene and PANSS positive and dopamine beta-hydroxylase with PANSS negative scores (p = 0.004 and p = 0.008, respectively). CONCLUSIONS: In conclusion, no major association was observed between the investigated variations and the efficacy profile of haloperidol.

RATIONALE: The antipsychotic pharmacological treatment effectiveness and side effects are at least partially driven by the genetic personal background. OBJECTIVES: In the present study, 71 genetic variations located in 21 candidate genes were investigated as modulators of the haloperidol efficacy and side effects in a sample of 101 acutely ill psychotic patients. METHODS: Patients were assessed at days 0, 7, 14, 21, and 28 (Positive and Negative Syndrome Scale (PANSS) test) and days 1, 3, 7, 14, 21, and 28 (UKU, BAS, and ESRS tests). Haloperidol plasma levels were measured at the same timepoints. RESULTS: None of the 71 variations were associated with response to treatment or with incidence of side effects passed a multiple testing threshold. A marginal association was detected between two haplotypes within the signal transducer and activator of transcription 4 gene and PANSS positive and dopamine beta-hydroxylase with PANSS negative scores (p = 0.004 and p = 0.008, respectively). CONCLUSIONS: In conclusion, no major association was observed between the investigated variations and the efficacy profile of haloperidol.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Response Genetics
Dewey Decimal Classification:Unspecified
Language:English
Date:2011
Deposited On:27 Feb 2011 13:26
Last Modified:05 Apr 2016 14:50
Publisher:Springer
ISSN:0033-3158
Publisher DOI:10.1007/s00213-010-2080-8
PubMed ID:21079921

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