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Early improvement in the first 2 weeks as a predictor of treatment outcome in patients with major depressive disorder: a meta-analysis including 6562 patients


Szegedi, A; Jansen, W T; Van Willigenburg, A P P; Van der Meulen, E; Stassen, H H; Thase, M E (2009). Early improvement in the first 2 weeks as a predictor of treatment outcome in patients with major depressive disorder: a meta-analysis including 6562 patients. Journal of Clinical Psychiatry, 70(3):344-353.

Abstract

These results indicate that early improvement with antidepressant medication can predict subsequent treatment outcome with high sensitivity in patients with major depressive disorder. The high negative predictive values indicate little chance of stable response or stable remission in the absence of improvement within 2 weeks. A lack of improvement during the first 2 weeks of therapy may indicate that changes in depression management should be considered earlier than conventionally thought.

These results indicate that early improvement with antidepressant medication can predict subsequent treatment outcome with high sensitivity in patients with major depressive disorder. The high negative predictive values indicate little chance of stable response or stable remission in the absence of improvement within 2 weeks. A lack of improvement during the first 2 weeks of therapy may indicate that changes in depression management should be considered earlier than conventionally thought.

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130 citations in Web of Science®
144 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Response Genetics
Dewey Decimal Classification:Unspecified
Language:English
Date:2009
Deposited On:08 Mar 2011 16:00
Last Modified:05 Apr 2016 14:50
Publisher:Physicians Postgraduate Press
ISSN:0160-6689
Publisher DOI:https://doi.org/10.4088/JCP.07m03780
PubMed ID:19254516

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