Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-4717
von Wegerer, J; Becker, K; Glockenhammer, D; Becker, C M; Zeilhofer, H U; Swandulla, D (2003). Spinal inhibitory synaptic transmission in the glycine receptor mouse mutant spastic. Neuroscience Letters, 345(1):45-48.
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Inhibitory glycine receptor (GlyR) and GABA(A) receptor (GABA(A)R)-mediated synaptic transmission was examined in two strains of the GlyR mutant mouse spastic and the respective wild types. The mutants display a mild and a severe neurological phenotype. Electrically evoked postsynaptic whole-cell currents were recorded from alpha-motoneurons in lumbar spinal cord slices. Amplitudes of GlyR-mediated IPSCs were significantly reduced in the severe phenotype in comparison to the respective wild type and the mild phenotype mutants. Surprisingly, amplitudes of GABA(A)R-mediated IPSCs were also significantly reduced in both mutants. Fast time constants of the decay phase of IPSCs were slightly reduced for the GlyR-mediated IPSCs and significantly larger for the GABA(A)R-mediated IPSCs in both mutant strains.
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|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > Institute of Pharmacology and Toxicology|
|DDC:||570 Life sciences; biology
610 Medicine & health
|Date:||10 July 2003|
|Deposited On:||03 Jan 2009 13:47|
|Last Modified:||23 Nov 2012 13:53|
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