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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-4717

von Wegerer, J; Becker, K; Glockenhammer, D; Becker, C M; Zeilhofer, H U; Swandulla, D (2003). Spinal inhibitory synaptic transmission in the glycine receptor mouse mutant spastic. Neuroscience Letters, 345(1):45-48.

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Inhibitory glycine receptor (GlyR) and GABA(A) receptor (GABA(A)R)-mediated synaptic transmission was examined in two strains of the GlyR mutant mouse spastic and the respective wild types. The mutants display a mild and a severe neurological phenotype. Electrically evoked postsynaptic whole-cell currents were recorded from alpha-motoneurons in lumbar spinal cord slices. Amplitudes of GlyR-mediated IPSCs were significantly reduced in the severe phenotype in comparison to the respective wild type and the mild phenotype mutants. Surprisingly, amplitudes of GABA(A)R-mediated IPSCs were also significantly reduced in both mutants. Fast time constants of the decay phase of IPSCs were slightly reduced for the GlyR-mediated IPSCs and significantly larger for the GABA(A)R-mediated IPSCs in both mutant strains.


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Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Date:10 July 2003
Deposited On:03 Jan 2009 13:47
Last Modified:05 Apr 2016 12:31
Publisher DOI:10.1016/S0304-3940(03)00499-3
PubMed ID:12809985

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