Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-47333
Kuhbier, J W; Allmeling, C; Reimers, K; Hillmer, A; Kasper, C; Menger, B; Brandes, G; Guggenheim, M; Vogt, P M (2010). Interactions between spider silk and cells--NIH/3T3 fibroblasts seeded on miniature weaving frames. PLoS ONE, 5(8):e12032.
Native spider silk does not require any modification to its application as a biomaterial that can rival any artificial material in terms of cell growth promoting properties. We could show adhesion mechanics on intracellular level. Additionally, proliferation kinetics were higher than in enzymatically digested controls, indicating that spider silk does not require modification. Recent findings concerning reduction of cell proliferation after exposure could not be met. As biotechnological production of the hierarchical composition of native spider silk fibres is still a challenge, our study has a pioneer role in researching cellular mechanics on native spider silk fibres.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Division of Surgical Research|
04 Faculty of Medicine > University Hospital Zurich > Clinic for Reconstructive Surgery
|DDC:||610 Medicine & health|
|Date:||09 August 2010|
|Deposited On:||04 Mar 2011 09:17|
|Last Modified:||03 Dec 2013 06:01|
|Publisher:||Public Library of Science|
|Citations:||Web of Science®. Times cited: 6|
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