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Prostaglandin E2 inhibits migration of colonic lamina propria fibroblasts


Rieder, F; Georgieva, M; Schirbel, A; Artinger, M; Zügner, A; Blank, M; Brenmoehl, J; Schölmerich, J; Rogler, G (2010). Prostaglandin E2 inhibits migration of colonic lamina propria fibroblasts. Inflammatory Bowel Diseases, 16(9):1505-1513.

Abstract

PGE2 reduced the migration of CLPF via elevation of intracellular cAMP. Potential mechanisms are changes in expression of cytoskeletal proteins, failure of CLPF to polarize, and a decreased amount of pMLC. This might be a possible reason for the impairment of intestinal wound healing in IBD.

PGE2 reduced the migration of CLPF via elevation of intracellular cAMP. Potential mechanisms are changes in expression of cytoskeletal proteins, failure of CLPF to polarize, and a decreased amount of pMLC. This might be a possible reason for the impairment of intestinal wound healing in IBD.

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15 citations in Web of Science®
17 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Gastroenterology and Hepatology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2010
Deposited On:04 Mar 2011 08:21
Last Modified:05 Apr 2016 14:52
Publisher:Wiley-Blackwell
ISSN:1078-0998
Publisher DOI:https://doi.org/10.1002/ibd.21255
PubMed ID:20803697

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