Rieder, F; Georgieva, M; Schirbel, A; Artinger, M; Zügner, A; Blank, M; Brenmoehl, J; Schölmerich, J; Rogler, G (2010). Prostaglandin E2 inhibits migration of colonic lamina propria fibroblasts. Inflammatory Bowel Diseases, 16(9):1505-1513.
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Abstract
PGE2 reduced the migration of CLPF via elevation of intracellular cAMP. Potential mechanisms are changes in expression of cytoskeletal proteins, failure of CLPF to polarize, and a decreased amount of pMLC. This might be a possible reason for the impairment of intestinal wound healing in IBD.
| Item Type: | Journal Article, refereed, original work |
|---|---|
| Communities & Collections: | 04 Faculty of Medicine > University Hospital Zurich > Clinic for Gastroenterology and Hepatology |
| DDC: | 610 Medicine & health |
| Language: | English |
| Date: | 2010 |
| Deposited On: | 04 Mar 2011 09:21 |
| Last Modified: | 23 Nov 2012 13:25 |
| Publisher: | Wiley-Blackwell |
| ISSN: | 1078-0998 |
| Publisher DOI: | 10.1002/ibd.21255 |
| PubMed ID: | 20803697 |
| WoS Citation Count: | 3 |
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