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Rieder, F; Georgieva, M; Schirbel, A; Artinger, M; Zügner, A; Blank, M; Brenmoehl, J; Schölmerich, J; Rogler, G (2010). Prostaglandin E2 inhibits migration of colonic lamina propria fibroblasts. Inflammatory Bowel Diseases, 16(9):1505-1513.

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PGE2 reduced the migration of CLPF via elevation of intracellular cAMP. Potential mechanisms are changes in expression of cytoskeletal proteins, failure of CLPF to polarize, and a decreased amount of pMLC. This might be a possible reason for the impairment of intestinal wound healing in IBD.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Gastroenterology and Hepatology
DDC:610 Medicine & health
Deposited On:04 Mar 2011 08:21
Last Modified:27 Nov 2013 18:24
Publisher DOI:10.1002/ibd.21255
PubMed ID:20803697
Citations:Web of Science®. Times Cited: 10
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Scopus®. Citation Count: 13

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