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Erythropoietic and non-erythropoietic functions of erythropoietin (Epo) in mouse models


Vogel, J; Gassmann, M (2011). Erythropoietic and non-erythropoietic functions of erythropoietin (Epo) in mouse models. Journal of Physiology, 589(6):1259-1264.

Abstract

As erythropoietin's (Epo) basic function is stimulation of red blood cell production, systemic overexpression of Epo results in erythrocytosis. The patho-physiological consequences of chronically elevated red blood cell counts have been studied in Epo overexpressing mice. Genetically modified mice, however, played also an important role in discovering multiple additional functions of Epo besides stimulating erythrocyte production. Non-erythropoietic functions of Epo are widespread and play a role in organogenesis during early embryonic development and in tissue protection in ischemic diseases. Future work in the field will most likely focus on these additional functions of Epo that harbor a great clinical potential.

As erythropoietin's (Epo) basic function is stimulation of red blood cell production, systemic overexpression of Epo results in erythrocytosis. The patho-physiological consequences of chronically elevated red blood cell counts have been studied in Epo overexpressing mice. Genetically modified mice, however, played also an important role in discovering multiple additional functions of Epo besides stimulating erythrocyte production. Non-erythropoietic functions of Epo are widespread and play a role in organogenesis during early embryonic development and in tissue protection in ischemic diseases. Future work in the field will most likely focus on these additional functions of Epo that harbor a great clinical potential.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Center for Integrative Human Physiology
05 Vetsuisse Faculty > Institute of Veterinary Physiology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Date:2011
Deposited On:10 Mar 2011 15:15
Last Modified:05 Apr 2016 14:52
Publisher:Wiley-Blackwell
ISSN:0022-3751
Additional Information:The definitive version is available at www.blackwell-synergy.com
Publisher DOI:10.1113/jphysiol.2010.196147
PubMed ID:21282290
Permanent URL: http://doi.org/10.5167/uzh-47504

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