Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-47504
Vogel, J; Gassmann, M (2011). Erythropoietic and non-erythropoietic functions of erythropoietin (Epo) in mouse models. Journal of Physiology, 589(6):1259-1264.
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As erythropoietin's (Epo) basic function is stimulation of red blood cell production, systemic overexpression of Epo results in erythrocytosis. The patho-physiological consequences of chronically elevated red blood cell counts have been studied in Epo overexpressing mice. Genetically modified mice, however, played also an important role in discovering multiple additional functions of Epo besides stimulating erythrocyte production. Non-erythropoietic functions of Epo are widespread and play a role in organogenesis during early embryonic development and in tissue protection in ischemic diseases. Future work in the field will most likely focus on these additional functions of Epo that harbor a great clinical potential.
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|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > Center for Integrative Human Physiology
05 Vetsuisse Faculty > Institute of Veterinary Physiology
|DDC:||570 Life sciences; biology
610 Medicine & health
|Deposited On:||10 Mar 2011 15:15|
|Last Modified:||27 Nov 2013 23:53|
|Additional Information:||The definitive version is available at www.blackwell-synergy.com|
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