Quick Search:

uzh logo
Browse by:

Zurich Open Repository and Archive

Maintenance: Tuesday, 5.7.2016, 07:00-08:00

Maintenance work on ZORA and JDB on Tuesday, 5th July, 07h00-08h00. During this time there will be a brief unavailability for about 1 hour. Please be patient.

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-47965

Affolter, M; Basler, K (2011). Cell biology. Cytonemes show their colors. Science, 332(6027):312-313.

[img]Published Version
PDF - Registered users only
View at publisher


Cells in multicellular organisms need to communicate in order to generate organs and tissues of appropriate shape and function. The “information” content of the communication consists of modulating the activity of biochemical signaling pathways. The “hardware” that is used to convey and collect such signals sometimes includes specialized structures, such as the synapses of neurons and molecular complexes that enable cells to adhere to each other or other surfaces. In many instances, cells actively explore their environment by producing extensions such as filopodia, lamellipodia, axons, and dendrites. The exact role of such extensions in non-neuronal cells remains, in most cases, unexplored. On page 354 of this issue, Roy et al. (1) help fill in some of the blanks. They report on the properties of filopodial extensions in the wing, eye, and tracheal system of Drosophila. They show that these extensions are dedicated to certain signaling pathways by the segregation of the corresponding receptors on their surfaces. The authors call these cell projections, which are based on the protein actin, cytonemes (Latin for “cell thread”). Their findings point to a scenario in which cells produce a signaling molecule that triggers other cells in the vicinity to form cytonemes, which ultimately become stable and are used for propagating specific intercellular signals.


7 citations in Web of Science®
8 citations in Scopus®
Google Scholar™



2 downloads since deposited on 02 May 2011
0 downloads since 12 months

Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
Dewey Decimal Classification:570 Life sciences; biology
Deposited On:02 May 2011 13:14
Last Modified:05 Apr 2016 14:54
Publisher:American Association for the Advancement of Science (AAAS)
Publisher DOI:10.1126/science.1205971
PubMed ID:21493848

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page