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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-48055

Müller, U C; Asherson, P; Banaschewski, T; Buitelaar, J K; Ebstein, R P; Eisenberg, J; Gill, M; Manor, I; Miranda, A; Oades, R D; Roeyers, H; Rothenberger, A; Sergeant, J A; Sonuga-Barke, E J S; Thompson, M; Faraone, S V; Steinhausen, H C (2011). The impact of study design and diagnostic approach in a large multi-centre ADHD study: Part 2: Dimensional measures of psychopathology and intelligence. BMC Psychiatry, 11:55.

Published Version


When ADHD probands are diagnosed by use of fixed symptom counts, the severity of the disorder in the proband sample may markedly differ between boys and girls and across age, particularly in samples with a large age range. A multi-centre design carries the risk of considerable phenotypic differences between centres and, consequently, of additional heterogeneity of the sample even if standardized diagnostic procedures are used. These possible sources of variance should be counteracted in genetic analyses either by using age and gender adjusted diagnostic procedures and regional normative data or by adjusting for design artefacts by use of covariate statistics, by eliminating outliers, or by other methods suitable for reducing heterogeneity.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Center for Child and Adolescent Psychiatry
DDC:610 Medicine & health
Deposited On:12 May 2011 13:36
Last Modified:27 Nov 2013 20:51
Publisher:BioMed Central
Publisher DOI:10.1186/1471-244X-11-55
PubMed ID:21473746
Citations:Web of Science®. Times Cited: 11
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Scopus®. Citation Count: 8

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